RNASE4 (gene)

Ribonuclease, RNase A family, 4, also known as RNASE4, is a human gene.cite web | title = Entrez Gene: RNASE4 ribonuclease, RNase A family, 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6038| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the pancreatic ribonuclease family. It plays an important role in mRNA cleavage and has marked specificity towards the 3' side of uridine nucleotides. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes angiogenin share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.cite web | title = Entrez Gene: RNASE4 ribonuclease, RNase A family, 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6038| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Shapiro R, Fett JW, Strydom DJ, Vallee BL |title=Isolation and characterization of a human colon carcinoma-secreted enzyme with pancreatic ribonuclease-like activity. |journal=Biochemistry |volume=25 |issue= 23 |pages= 7255–64 |year= 1987 |pmid= 3467790 |doi=
*cite journal | author=Rosenberg HF, Dyer KD |title=Human ribonuclease 4 (RNase 4): coding sequence, chromosomal localization and identification of two distinct transcripts in human somatic tissues. |journal=Nucleic Acids Res. |volume=23 |issue= 21 |pages= 4290–5 |year= 1996 |pmid= 7501448 |doi=
*cite journal | author=Seno M, Futami J, Tsushima Y, "et al." |title=Molecular cloning and expression of human ribonuclease 4 cDNA. |journal=Biochim. Biophys. Acta |volume=1261 |issue= 3 |pages= 424–6 |year= 1995 |pmid= 7742370 |doi=
*cite journal | author=Zhou HM, Strydom DJ |title=The amino acid sequence of human ribonuclease 4, a highly conserved ribonuclease that cleaves specifically on the 3' side of uridine. |journal=Eur. J. Biochem. |volume=217 |issue= 1 |pages= 401–10 |year= 1993 |pmid= 8223579 |doi=
*cite journal | author=Egesten A, Dyer KD, Batten D, "et al." |title=Ribonucleases and host defense: identification, localization and gene expression in adherent monocytes in vitro. |journal=Biochim. Biophys. Acta |volume=1358 |issue= 3 |pages= 255–60 |year= 1997 |pmid= 9366257 |doi=
*cite journal | author=Terzyan SS, Peracaula R, de Llorens R, "et al." |title=The three-dimensional structure of human RNase 4, unliganded and complexed with d(Up), reveals the basis for its uridine selectivity. |journal=J. Mol. Biol. |volume=285 |issue= 1 |pages= 205–14 |year= 1999 |pmid= 9878400 |doi= 10.1006/jmbi.1998.2288
*cite journal | author=Xu XR, Huang J, Xu ZG, "et al." |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089–94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209

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