C12orf5

Chromosome 12 open reading frame 5, also known as C12orf5, is a human gene.

PBB_Summary
section_title =
summary_text = This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.cite web | title = Entrez Gene: C12orf5 chromosome 12 open reading frame 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57103| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Green DR, Chipuk JE |title=p53 and metabolism: Inside the TIGAR. |journal=Cell |volume=126 |issue= 1 |pages= 30–2 |year= 2006 |pmid= 16839873 |doi= 10.1016/j.cell.2006.06.032
*cite journal | author= Econs, Michael J.|title=Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. |journal=Nat. Genet. |volume=26 |issue= 3 |pages= 345–8 |year= 2000 |pmid= 11062477 |doi= 10.1038/81664
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Katoh Y, Katoh M |title=Comparative genomics on mammalian Fgf6-Fgf23 locus. |journal=Int. J. Mol. Med. |volume=16 |issue= 2 |pages= 355–8 |year= 2005 |pmid= 16012775 |doi=
*cite journal | author=Jen KY, Cheung VG |title=Identification of novel p53 target genes in ionizing radiation response. |journal=Cancer Res. |volume=65 |issue= 17 |pages= 7666–73 |year= 2005 |pmid= 16140933 |doi= 10.1158/0008-5472.CAN-05-1039 | doi_brokendate=2008-10-03
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Bensaad K, Tsuruta A, Selak MA, "et al." |title=TIGAR, a p53-inducible regulator of glycolysis and apoptosis. |journal=Cell |volume=126 |issue= 1 |pages= 107–20 |year= 2006 |pmid= 16839880 |doi= 10.1016/j.cell.2006.05.036

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