ACTL6B

Actin-like 6B, also known as ACTL6B, is a human gene.cite web | title = Entrez Gene: ACTL6B actin-like 6B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51412| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.cite web | title = Entrez Gene: ACTL6B actin-like 6B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51412| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schafer DA, Schroer TA |title=Actin-related proteins. |journal=Annu. Rev. Cell Dev. Biol. |volume=15 |issue= |pages= 341–63 |year= 2000 |pmid= 10611965 |doi= 10.1146/annurev.cellbio.15.1.341
*cite journal | author=Glöckner G, Scherer S, Schattevoy R, "et al." |title=Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. |journal=Genome Res. |volume=8 |issue= 10 |pages= 1060–73 |year= 1998 |pmid= 9799793 |doi=
*cite journal | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=
*cite journal | author=Harata M, Mochizuki R, Mizuno S |title=Two isoforms of a human actin-related protein show nuclear localization and mutually selective expression between brain and other tissues. |journal=Biosci. Biotechnol. Biochem. |volume=63 |issue= 5 |pages= 917–23 |year= 1999 |pmid= 10380635 |doi=
*cite journal | author=Olave I, Wang W, Xue Y, "et al." |title=Identification of a polymorphic, neuron-specific chromatin remodeling complex. |journal=Genes Dev. |volume=16 |issue= 19 |pages= 2509–17 |year= 2002 |pmid= 12368262 |doi= 10.1101/gad.992102
*cite journal | author=Kuroda Y, Oma Y, Nishimori K, "et al." |title=Brain-specific expression of the nuclear actin-related protein ArpNalpha and its involvement in mammalian SWI/SNF chromatin remodeling complex. |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 2 |pages= 328–34 |year= 2003 |pmid= 12437990 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Oma Y, Nishimori K, Harata M |title=The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 2 |pages= 521–8 |year= 2003 |pmid= 12565893 |doi=
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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