GFRA2 (gene)

GDNF family receptor alpha 2, also known as GFRA2, is a human gene.cite web | title = Entrez Gene: GFRA2 GDNF family receptor alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2675| accessdate = ]

PBB_Summary
section_title =
summary_text = Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases.cite web | title = Entrez Gene: GFRA2 GDNF family receptor alpha 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2675| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sanicola M, Hession C, Worley D, "et al." |title=Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 12 |pages= 6238–43 |year= 1997 |pmid= 9177201 |doi=
*cite journal | author=Baloh RH, Tansey MG, Golden JP, "et al." |title=TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. |journal=Neuron |volume=18 |issue= 5 |pages= 793–802 |year= 1997 |pmid= 9182803 |doi=
*cite journal | author=Klein RD, Sherman D, Ho WH, "et al." |title=A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. |journal=Nature |volume=387 |issue= 6634 |pages= 717–21 |year= 1997 |pmid= 9192898 |doi= 10.1038/42722
*cite journal | author=Suvanto P, Wartiovaara K, Lindahl M, "et al." |title=Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha. |journal=Hum. Mol. Genet. |volume=6 |issue= 8 |pages= 1267–73 |year= 1997 |pmid= 9259272 |doi=
*cite journal | author=Jing S, Yu Y, Fang M, "et al." |title=GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 33111–7 |year= 1998 |pmid= 9407096 |doi=
*cite journal | author=Tansey MG, Baloh RH, Milbrandt J, Johnson EM |title=GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival. |journal=Neuron |volume=25 |issue= 3 |pages= 611–23 |year= 2000 |pmid= 10774729 |doi=
*cite journal | author=Cik M, Masure S, Lesage AS, "et al." |title=Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions. |journal=J. Biol. Chem. |volume=275 |issue= 36 |pages= 27505–12 |year= 2000 |pmid= 10829012 |doi= 10.1074/jbc.M000306200
*cite journal | author=Vanhorne JB, Gimm O, Myers SM, "et al." |title=Cloning and characterization of the human GFRA2 locus and investigation of the gene in Hirschsprung disease. |journal=Hum. Genet. |volume=108 |issue= 5 |pages= 409–15 |year= 2001 |pmid= 11409869 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Yoong LF, Too HP |title=Glial cell line-derived neurotrophic factor and neurturin inhibit neurite outgrowth and activate RhoA through GFR alpha 2b, an alternatively spliced isoform of GFR alpha 2. |journal=J. Neurosci. |volume=27 |issue= 21 |pages= 5603–14 |year= 2007 |pmid= 17522305 |doi= 10.1523/JNEUROSCI.4552-06.2007

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes