STAP1

BCR downstream signaling 1, also known as BRDG1, is a human gene.cite web | title = Entrez Gene: BRDG1 BCR downstream signaling 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26228| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart.cite web | title = Entrez Gene: BRDG1 BCR downstream signaling 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26228| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kurosaki T |title=Genetic analysis of B cell antigen receptor signaling. |journal=Annu. Rev. Immunol. |volume=17 |issue= |pages= 555–92 |year= 1999 |pmid= 10358768 |doi= 10.1146/annurev.immunol.17.1.555
*cite journal | author=Ohya K, Kajigaya S, Kitanaka A, "et al." |title=Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 21 |pages= 11976–81 |year= 1999 |pmid= 10518561 |doi=
*cite journal | author=Masuhara M, Nagao K, Nishikawa M, "et al." |title=Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 3 |pages= 697–703 |year= 2000 |pmid= 10679268 |doi= 10.1006/bbrc.2000.2223
*cite journal | author=Harrington JJ, Sherf B, Rundlett S, "et al." |title=Creation of genome-wide protein expression libraries using random activation of gene expression. |journal=Nat. Biotechnol. |volume=19 |issue= 5 |pages= 440–5 |year= 2001 |pmid= 11329013 |doi= 10.1038/88107
*cite journal | author=Yokohari K, Yamashita Y, Okada S, "et al." |title=Isoform-dependent interaction of BRDG1 with Tec kinase. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 2 |pages= 414–20 |year= 2002 |pmid= 11716489 |doi= 10.1006/bbrc.2001.6008
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Minoguchi M, Minoguchi S, Aki D, "et al." |title=STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11182–9 |year= 2003 |pmid= 12540842 |doi= 10.1074/jbc.M211230200
*cite journal | author=Gstaiger M, Luke B, Hess D, "et al." |title=Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. |journal=Science |volume=302 |issue= 5648 |pages= 1208–12 |year= 2003 |pmid= 14615539 |doi= 10.1126/science.1088401
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Ma J, Dempsey AA, Stamatiou D, "et al." |title=Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. |journal=Atherosclerosis |volume=191 |issue= 1 |pages= 63–72 |year= 2007 |pmid= 16806233 |doi= 10.1016/j.atherosclerosis.2006.05.032
*cite journal | author=Beausoleil SA, Villén J, Gerber SA, "et al." |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240

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