FBXW2

F-box and WD repeat domain containing 2, also known as FBXW2, is a human gene.

PBB_Summary
section_title =
summary_text = F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats.cite web | title = Entrez Gene: FBXW2 F-box and WD repeat domain containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26190| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Patton EE, Willems AR, Tyers M |title=Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis. |journal=Trends Genet. |volume=14 |issue= 6 |pages= 236–43 |year= 1998 |pmid= 9635407 |doi=10.1016/S0168-9525(98)01473-5
*cite journal | author=Cenciarelli C, Chiaur DS, Guardavaccaro D, "et al." |title=Identification of a family of human F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1177–9 |year= 1999 |pmid= 10531035 |doi= 10.1016/S0960-9822(00)80020-2
*cite journal | author=Winston JT, Koepp DM, Zhu C, "et al." |title=A family of mammalian F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180–2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4
*cite journal | author=Chiaur DS, Murthy S, Cenciarelli C, "et al." |title=Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 255–8 |year= 2000 |pmid= 10828603 |doi=10.1159/000015532
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Busino L, Donzelli M, Chiesa M, "et al." |title=Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. |journal=Nature |volume=426 |issue= 6962 |pages= 87–91 |year= 2003 |pmid= 14603323 |doi= 10.1038/nature02082
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Watanabe N, Arai H, Nishihara Y, "et al." |title=M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 13 |pages= 4419–24 |year= 2004 |pmid= 15070733 |doi= 10.1073/pnas.0307700101
*cite journal | author=Yang CS, Yu C, Chuang HC, "et al." |title=FBW2 targets GCMa to the ubiquitin-proteasome degradation system. |journal=J. Biol. Chem. |volume=280 |issue= 11 |pages= 10083–90 |year= 2005 |pmid= 15640526 |doi= 10.1074/jbc.M413986200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406

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