CLCF1

Cardiotrophin-like cytokine factor 1, also known as CLCF1, is a human gene.cite web | title = Entrez Gene: CLCF1 cardiotrophin-like cytokine factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23529| accessdate = ]

PBB_Summary
section_title =
summary_text = CLC belongs to the interleukin-6 (IL6; MIM 147620) family of cytokines, which are involved in cell signaling through phosphorylation of gp130 (MIM 162820). IL6 family members share similarity in gene structure and have a 4-helix bundle in their protein structure. [supplied by OMIM] cite web | title = Entrez Gene: CLCF1 cardiotrophin-like cytokine factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23529| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Shi Y, Wang W, Yourey PA, "et al." |title=Computational EST database analysis identifies a novel member of the neuropoietic cytokine family. |journal=Biochem. Biophys. Res. Commun. |volume=262 |issue= 1 |pages= 132–8 |year= 1999 |pmid= 10448081 |doi= 10.1006/bbrc.1999.1181
*cite journal | author=Senaldi G, Varnum BC, Sarmiento U, "et al." |title=Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 20 |pages= 11458–63 |year= 1999 |pmid= 10500198 |doi=
*cite journal | author=Elson GC, Lelièvre E, Guillet C, "et al." |title=CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex. |journal=Nat. Neurosci. |volume=3 |issue= 9 |pages= 867–72 |year= 2000 |pmid= 10966616 |doi= 10.1038/78765
*cite journal | author=Plun-Favreau H, Elson G, Chabbert M, "et al." |title=The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine. |journal=EMBO J. |volume=20 |issue= 7 |pages= 1692–703 |year= 2001 |pmid= 11285233 |doi= 10.1093/emboj/20.7.1692
*cite journal | author=Lelièvre E, Plun-Favreau H, Chevalier S, "et al." |title=Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22476–84 |year= 2001 |pmid= 11294841 |doi= 10.1074/jbc.M101681200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Auernhammer CJ, Isele NB, Kopp FB, "et al." |title=Novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) stimulates corticotroph function via a signal transducer and activator of transcription-dependent mechanism negatively regulated by suppressor of cytokine signaling-3. |journal=Endocrinology |volume=144 |issue= 4 |pages= 1202–10 |year= 2003 |pmid= 12639901 |doi=
*cite journal | author=Burger R, Bakker F, Guenther A, "et al." |title=Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival. |journal=Br. J. Haematol. |volume=123 |issue= 5 |pages= 869–78 |year= 2004 |pmid= 14632778 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rousseau F, Gauchat JF, McLeod JG, "et al." |title=Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 26 |pages= 10068–73 |year= 2006 |pmid= 16782820 |doi= 10.1073/pnas.0509598103
*cite journal | author=Dagoneau N, Bellais S, Blanchet P, "et al." |title=Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes. |journal=Am. J. Hum. Genet. |volume=80 |issue= 5 |pages= 966–70 |year= 2007 |pmid= 17436251 |doi= 10.1086/513608

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