ELA3B

Elastase 3B, pancreatic, also known as ELA3B, is a human gene.cite web | title = Entrez Gene: ELA3B elastase 3B, pancreatic| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23436| accessdate = ]

PBB_Summary
section_title =
summary_text = Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1.cite web | title = Entrez Gene: ELA3B elastase 3B, pancreatic| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23436| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Shirasu Y, Takemura K, Yoshida H, "et al." |title=Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes. |journal=J. Biochem. |volume=104 |issue= 2 |pages= 259–64 |year= 1988 |pmid= 2460440 |doi=
*cite journal | author=Avilés FX, Pascual R, Salva M, "et al." |title=Generation of a subunit III-like protein by autolysis of human and porcine proproteinase e in a binary complex with procarboxypeptidase A. |journal=Biochem. Biophys. Res. Commun. |volume=163 |issue= 3 |pages= 1191–6 |year= 1989 |pmid= 2675835 |doi=
*cite journal | author=Wendorf P, Geyer R, Sziegoleit A, Linder D |title=Localization and characterization of the glycosylation site of human pancreatic elastase 1. |journal=FEBS Lett. |volume=249 |issue= 2 |pages= 275–8 |year= 1989 |pmid= 2737288 |doi=
*cite journal | author=Moulard M, Kerfelec B, Mallet B, Chapus C |title=Identification of a procarboxypeptidase A-truncated protease E binary complex in human pancreatic juice. |journal=FEBS Lett. |volume=250 |issue= 2 |pages= 166–70 |year= 1989 |pmid= 2753124 |doi=
*cite journal | author=Tani T, Ohsumi J, Mita K, Takiguchi Y |title=Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning. |journal=J. Biol. Chem. |volume=263 |issue= 3 |pages= 1231–9 |year= 1988 |pmid= 2826474 |doi=
*cite journal | author=Guy-Crotte O, Barthe C, Basso D, "et al." |title=Characterization of two glycoproteins of human pancreatic juice: P35, a truncated protease E and P19, precursor of protein X. |journal=Biochem. Biophys. Res. Commun. |volume=156 |issue= 1 |pages= 318–22 |year= 1988 |pmid= 3178837 |doi=
*cite journal | author=Shen WF, Fletcher TS, Largman C |title=Primary structure of human pancreatic protease E determined by sequence analysis of the cloned mRNA. |journal=Biochemistry |volume=26 |issue= 12 |pages= 3447–52 |year= 1987 |pmid= 3477287 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727

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