SLITRK1 (gene)

SLIT and NTRK-like family, member 1, also known as SLITRK1, is a human gene.cite web | title = Entrez Gene: SLITRK1 SLIT and NTRK-like family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114798| accessdate = ]

PBB_Summary
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summary_text = Members of the SLITRK family, such as SLITRK1, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, but not SLITRK1, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003). [supplied by OMIM] cite web | title = Entrez Gene: SLITRK1 SLIT and NTRK-like family, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114798| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nagase T, Kikuno R, Ohara O |title=Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. |journal=DNA Res. |volume=8 |issue= 4 |pages= 179–87 |year= 2002 |pmid= 11572484 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Aruga J, Mikoshiba K |title=Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth. |journal=Mol. Cell. Neurosci. |volume=24 |issue= 1 |pages= 117–29 |year= 2004 |pmid= 14550773 |doi=
*cite journal | author=Aruga J, Yokota N, Mikoshiba K |title=Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue. |journal=Gene |volume=315 |issue= |pages= 87–94 |year= 2004 |pmid= 14557068 |doi=
*cite journal | author=Dunham A, Matthews LH, Burton J, "et al." |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Abelson JF, Kwan KY, O'Roak BJ, "et al." |title=Sequence variants in SLITRK1 are associated with Tourette's syndrome. |journal=Science |volume=310 |issue= 5746 |pages= 317–20 |year= 2005 |pmid= 16224024 |doi= 10.1126/science.1116502
*cite journal | author=Burton A |title=SLITRK1 trouble in Tourette's syndrome. |journal=Lancet neurology |volume=4 |issue= 12 |pages= 801 |year= 2006 |pmid= 16323357 |doi=
*cite journal | author=Wendland JR, Kruse MR, Murphy DL |title=Functional SLITRK1 var321, varCDfs and SLC6A4 G56A variants and susceptibility to obsessive-compulsive disorder. |journal=Mol. Psychiatry |volume=11 |issue= 9 |pages= 802–4 |year= 2006 |pmid= 16936762 |doi= 10.1038/sj.mp.4001848
*cite journal | author=Zuchner S, Cuccaro ML, Tran-Viet KN, "et al." |title=SLITRK1 mutations in trichotillomania. |journal=Mol. Psychiatry |volume=11 |issue= 10 |pages= 887–9 |year= 2006 |pmid= 17003809 |doi= 10.1038/sj.mp.4001865

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