TRIM22

PBB|geneid=10346

Tripartite motif-containing 22, also known as TRIM22, is a human gene.cite web | title = Entrez Gene: TRIM22 tripartite motif-containing 22| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10346| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects.cite web | title = Entrez Gene: TRIM22 tripartite motif-containing 22| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10346| accessdate = ]

According to researcher Stephen Barr, a molecular virologist in the Department of Medical Microbiology and Immunology, gene TRIM22 prevents the assembly of the HIV virus. [ [http://www.physorg.com/news123505489.html Researchers discover gene that blocks HIV ] ]

References

This stops it from moving throughout the body. This is the first time that scientists have found a naturally occurring gene that blocks HIV and it could prove essential in the fight against aids.

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tissot C, Mechti N |title=Molecular cloning of a new interferon-induced factor that represses human immunodeficiency virus type 1 long terminal repeat expression. |journal=J. Biol. Chem. |volume=270 |issue= 25 |pages= 14891–8 |year= 1995 |pmid= 7797467 |doi=
*cite journal | author=Tissot C, Taviaux SA, Diriong S, Mechti N |title=Localization of Staf50, a member of the Ring finger family, to 11p15 by fluorescence in situ hybridization. |journal=Genomics |volume=34 |issue= 1 |pages= 151–3 |year= 1996 |pmid= 8661041 |doi= 10.1006/geno.1996.0258
*cite journal | author=Gongora C, Tissot C, Cerdan C, Mechti N |title=The interferon-inducible Staf50 gene is downregulated during T cell costimulation by CD2 and CD28. |journal=J. Interferon Cytokine Res. |volume=20 |issue= 11 |pages= 955–61 |year= 2001 |pmid= 11096452 |doi= 10.1089/10799900050198390
*cite journal | author=Reymond A, Meroni G, Fantozzi A, "et al." |title=The tripartite motif family identifies cell compartments. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2140–51 |year= 2001 |pmid= 11331580 |doi= 10.1093/emboj/20.9.2140
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Izmailova E, Bertley FM, Huang Q, "et al." |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822
*cite journal | author=Obad S, Brunnström H, Vallon-Christersson J, "et al." |title=Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells. |journal=Oncogene |volume=23 |issue= 23 |pages= 4050–9 |year= 2004 |pmid= 15064739 |doi= 10.1038/sj.onc.1207524
*cite journal | author=Fu GK, Wang JT, Yang J, "et al." |title=Circular rapid amplification of cDNA ends for high-throughput extension cloning of partial genes. |journal=Genomics |volume=84 |issue= 1 |pages= 205–10 |year= 2005 |pmid= 15203218 |doi= 10.1016/j.ygeno.2004.01.011
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Bouazzaoui A, Kreutz M, Eisert V, "et al." |title=Stimulated trans-acting factor of 50 kDa (Staf50) inhibits HIV-1 replication in human monocyte-derived macrophages. |journal=Virology |volume=356 |issue= 1-2 |pages= 79–94 |year= 2007 |pmid= 16926043 |doi= 10.1016/j.virol.2006.07.025

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