TP53I3

Tumor protein p53 inducible protein 3, also known as TP53I3, is a human gene.cite web | title = Entrez Gene: TP53I3 tumor protein p53 inducible protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9540| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene.cite web | title = Entrez Gene: TP53I3 tumor protein p53 inducible protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9540| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Polyak K, Xia Y, Zweier JL, "et al." |title=A model for p53-induced apoptosis. |journal=Nature |volume=389 |issue= 6648 |pages= 300–5 |year= 1997 |pmid= 9305847 |doi= 10.1038/38525
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Flatt PM, Polyak K, Tang LJ, "et al." |title=p53-dependent expression of PIG3 during proliferation, genotoxic stress, and reversible growth arrest. |journal=Cancer Lett. |volume=156 |issue= 1 |pages= 63–72 |year= 2000 |pmid= 10840161 |doi=
*cite journal | author=Contente A, Dittmer A, Koch MC, "et al." |title=A polymorphic microsatellite that mediates induction of PIG3 by p53. |journal=Nat. Genet. |volume=30 |issue= 3 |pages= 315–20 |year= 2002 |pmid= 11919562 |doi= 10.1038/ng836
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nicholls CD, Shields MA, Lee PW, "et al." |title=UV-dependent alternative splicing uncouples p53 activity and PIG3 gene function through rapid proteolytic degradation. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24171–8 |year= 2004 |pmid= 15067011 |doi= 10.1074/jbc.M401049200
*cite journal | author=Pospísilová S, Siligan C, Ban J, "et al." |title=Constitutive and DNA damage inducible activation of pig3 and MDM2 genes by tumor-derived p53 mutant C277Y. |journal=Mol. Cancer Res. |volume=2 |issue= 5 |pages= 296–304 |year= 2004 |pmid= 15192123 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hillier LW, Graves TA, Fulton RS, "et al." |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466
*cite journal | author=Rohaly G, Chemnitz J, Dehde S, "et al." |title=A novel human p53 isoform is an essential element of the ATR-intra-S phase checkpoint. |journal=Cell |volume=122 |issue= 1 |pages= 21–32 |year= 2005 |pmid= 16009130 |doi= 10.1016/j.cell.2005.04.032
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029

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