PEX16

Peroxisomal biogenesis factor 16, also known as PEX16, is a human gene.cite web | title = Entrez Gene: PEX16 peroxisomal biogenesis factor 16| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9409| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is an integral peroxisomal membrane protein. An inactivating nonsense mutation localized to this gene was observed in a patient with Zellweger syndrome of the complementation group CGD/CG9. Expression of this gene product morphologically and biochemically restores the formation of new peroxisomes, suggesting a role in peroxisome organization and biogenesis. Alternative splicing has been observed for this gene and two variants have been described.cite web | title = Entrez Gene: PEX16 peroxisomal biogenesis factor 16| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9409| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Honsho M, Tamura S, Shimozawa N, "et al." |title=Mutation in PEX16 is causal in the peroxisome-deficient Zellweger syndrome of complementation group D. |journal=Am. J. Hum. Genet. |volume=63 |issue= 6 |pages= 1622–30 |year= 1999 |pmid= 9837814 |doi=
*cite journal | author=South ST, Gould SJ |title=Peroxisome synthesis in the absence of preexisting peroxisomes. |journal=J. Cell Biol. |volume=144 |issue= 2 |pages= 255–66 |year= 1999 |pmid= 9922452 |doi=
*cite journal | author=Sacksteder KA, Jones JM, South ST, "et al." |title=PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. |journal=J. Cell Biol. |volume=148 |issue= 5 |pages= 931–44 |year= 2000 |pmid= 10704444 |doi=
*cite journal | author=Fransen M, Wylin T, Brees C, "et al." |title=Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences. |journal=Mol. Cell. Biol. |volume=21 |issue= 13 |pages= 4413–24 |year= 2001 |pmid= 11390669 |doi= 10.1128/MCB.21.13.4413-4424.2001
*cite journal | author=Shimozawa N, Nagase T, Takemoto Y, "et al." |title=A novel aberrant splicing mutation of the PEX16 gene in two patients with Zellweger syndrome. |journal=Biochem. Biophys. Res. Commun. |volume=292 |issue= 1 |pages= 109–12 |year= 2002 |pmid= 11890679 |doi=
*cite journal | author=Fransen M, Brees C, Ghys K, "et al." |title=Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay. |journal=Mol. Cell Proteomics |volume=1 |issue= 3 |pages= 243–52 |year= 2002 |pmid= 12096124 |doi=
*cite journal | author=Honsho M, Hiroshige T, Fujiki Y |title=The membrane biogenesis peroxin Pex16p. Topogenesis and functional roles in peroxisomal membrane assembly. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44513–24 |year= 2003 |pmid= 12223482 |doi= 10.1074/jbc.M206139200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Jones JM, Morrell JC, Gould SJ |title=PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins. |journal=J. Cell Biol. |volume=164 |issue= 1 |pages= 57–67 |year= 2004 |pmid= 14709540 |doi= 10.1083/jcb.200304111
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Fransen M, Vastiau I, Brees C, "et al." |title=Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis. |journal=J. Mol. Biol. |volume=346 |issue= 5 |pages= 1275–86 |year= 2005 |pmid= 15713480 |doi= 10.1016/j.jmb.2005.01.013
*cite journal | author=Brocard CB, Boucher KK, Jedeszko C, "et al." |title=Requirement for microtubules and dynein motors in the earliest stages of peroxisome biogenesis. |journal=Traffic |volume=6 |issue= 5 |pages= 386–95 |year= 2005 |pmid= 15813749 |doi= 10.1111/j.1600-0854.2005.00283.x
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kim PK, Mullen RT, Schumann U, Lippincott-Schwartz J |title=The origin and maintenance of mammalian peroxisomes involves a de novo PEX16-dependent pathway from the ER. |journal=J. Cell Biol. |volume=173 |issue= 4 |pages= 521–32 |year= 2006 |pmid= 16717127 |doi= 10.1083/jcb.200601036

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