REPS2

RALBP1 associated Eps domain containing 2, also known as REPS2, is a human gene.cite web | title = Entrez Gene: REPS2 RALBP1 associated Eps domain containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9185| accessdate = ]

PBB_Summary
section_title =
summary_text = The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: REPS2 RALBP1 associated Eps domain containing 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9185| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ikeda M, Ishida O, Hinoi T, "et al." |title=Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral. |journal=J. Biol. Chem. |volume=273 |issue= 2 |pages= 814–21 |year= 1998 |pmid= 9422736 |doi=
*cite journal | author=Koshiba S, Kigawa T, Iwahara J, "et al." |title=Solution structure of the Eps15 homology domain of a human POB1 (partner of RalBP1). |journal=FEBS Lett. |volume=442 |issue= 2-3 |pages= 138–42 |year= 1999 |pmid= 9928989 |doi=
*cite journal | author=Nakashima S, Morinaka K, Koyama S, "et al." |title=Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. |journal=EMBO J. |volume=18 |issue= 13 |pages= 3629–42 |year= 1999 |pmid= 10393179 |doi= 10.1093/emboj/18.13.3629
*cite journal | author=Morinaka K, Koyama S, Nakashima S, "et al." |title=Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis. |journal=Oncogene |volume=18 |issue= 43 |pages= 5915–22 |year= 1999 |pmid= 10557078 |doi= 10.1038/sj.onc.1202974
*cite journal | author=Matsuzaki T, Hanai S, Kishi H, "et al." |title=Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway. |journal=J. Biol. Chem. |volume=277 |issue= 21 |pages= 19008–18 |year= 2002 |pmid= 11882656 |doi= 10.1074/jbc.M112472200
*cite journal | author=Oshiro T, Koyama S, Sugiyama S, "et al." |title=Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration. |journal=J. Biol. Chem. |volume=277 |issue= 41 |pages= 38618–26 |year= 2002 |pmid= 12149250 |doi= 10.1074/jbc.M203453200
*cite journal | author=Oosterhoff JK, Penninkhof F, Brinkmann AO, "et al." |title=REPS2/POB1 is downregulated during human prostate cancer progression and inhibits growth factor signalling in prostate cancer cells. |journal=Oncogene |volume=22 |issue= 19 |pages= 2920–5 |year= 2003 |pmid= 12771942 |doi= 10.1038/sj.onc.1206397
*cite journal | author=Rossé C, L'Hoste S, Offner N, "et al." |title=RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. |journal=J. Biol. Chem. |volume=278 |issue= 33 |pages= 30597–604 |year= 2003 |pmid= 12775724 |doi= 10.1074/jbc.M302191200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Penninkhof F, Grootegoed JA, Blok LJ |title=Identification of REPS2 as a putative modulator of NF-kappaB activity in prostate cancer cells. |journal=Oncogene |volume=23 |issue= 33 |pages= 5607–15 |year= 2004 |pmid= 15184881 |doi= 10.1038/sj.onc.1207750
*cite journal | author=Oosterhoff JK, Kühne LC, Grootegoed JA, Blok LJ |title=EGF signalling in prostate cancer cell lines is inhibited by a high expression level of the endocytosis protein REPS2. |journal=Int. J. Cancer |volume=113 |issue= 4 |pages= 561–7 |year= 2005 |pmid= 15455380 |doi= 10.1002/ijc.20612
*cite journal | author=Yadav S, Zajac E, Singhal SS, "et al." |title=POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis. |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 4 |pages= 1003–9 |year= 2005 |pmid= 15707977 |doi= 10.1016/j.bbrc.2005.01.055

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes