PRAM1

PML-RARA regulated adaptor molecule 1, also known as PRAM1, is a human gene.cite web | title = Entrez Gene: PRAM1 PML-RARA regulated adaptor molecule 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84106| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is similar to FYN binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha).cite web | title = Entrez Gene: PRAM1 PML-RARA regulated adaptor molecule 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84106| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Boddy MN, Howe K, Etkin LD, "et al." |title=PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia. |journal=Oncogene |volume=13 |issue= 5 |pages= 971–82 |year= 1996 |pmid= 8806687 |doi=
*cite journal | author=Cao T, Duprez E, Borden KL, "et al." |title=Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML. |journal=J. Cell. Sci. |volume=111 ( Pt 10) |issue= |pages= 1319–29 |year= 1998 |pmid= 9570750 |doi=
*cite journal | author=Moog-Lutz C, Peterson EJ, Lutz PG, "et al." |title=PRAM-1 is a novel adaptor protein regulated by retinoic acid (RA) and promyelocytic leukemia (PML)-RA receptor alpha in acute promyelocytic leukemia cells. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22375–81 |year= 2001 |pmid= 11301322 |doi= 10.1074/jbc.M011683200
*cite journal | author=Khan MM, Nomura T, Kim H, "et al." |title=Role of PML and PML-RARalpha in Mad-mediated transcriptional repression. |journal=Mol. Cell |volume=7 |issue= 6 |pages= 1233–43 |year= 2001 |pmid= 11430826 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Clemens RA, Newbrough SA, Chung EY, "et al." |title=PRAM-1 is required for optimal integrin-dependent neutrophil function. |journal=Mol. Cell. Biol. |volume=24 |issue= 24 |pages= 10923–32 |year= 2004 |pmid= 15572693 |doi= 10.1128/MCB.24.24.10923-10932.2004
*cite journal | author=Denis FM, Benecke A, Di Gioia Y, "et al." |title=PRAM-1 potentiates arsenic trioxide-induced JNK activation. |journal=J. Biol. Chem. |volume=280 |issue= 10 |pages= 9043–8 |year= 2005 |pmid= 15637062 |doi= 10.1074/jbc.M413564200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Rossi V, Levati L, Biondi A |title=Diagnosis and monitoring of PML-RARA-positive acute promyelocytic leukemia by qualitative RT-PCR. |journal=Methods Mol. Med. |volume=125 |issue= |pages= 115–26 |year= 2006 |pmid= 16502581 |doi=
*cite journal | author=Mokany E, Todd AV, Fuery CJ, Applegate TL |title=Diagnosis and monitoring of PML-RARalpha-positive acute promyelocytic leukemia by quantitative RT-PCR. |journal=Methods Mol. Med. |volume=125 |issue= |pages= 127–47 |year= 2006 |pmid= 16502582 |doi=
*cite journal | author=Heuer K, Sylvester M, Kliche S, "et al." |title=Lipid-binding hSH3 domains in immune cell adapter proteins. |journal=J. Mol. Biol. |volume=361 |issue= 1 |pages= 94–104 |year= 2006 |pmid= 16831444 |doi= 10.1016/j.jmb.2006.06.004

PBB_Controls
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