HSD17B8

Hydroxysteroid (17-beta) dehydrogenase 8, also known as HSD17B8, is a human gene.cite web | title = Entrez Gene: HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7923| accessdate = ]

PBB_Summary
section_title =
summary_text = In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined.cite web | title = Entrez Gene: HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7923| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ando A, Kikuti YY, Shigenari A, "et al." |title=cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. |journal=Genomics |volume=35 |issue= 3 |pages= 600–2 |year= 1996 |pmid= 8812499 |doi= 10.1006/geno.1996.0405
*cite journal | author=Kikuti YY, Tamiya G, Ando A, "et al." |title=Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes. |journal=Genomics |volume=42 |issue= 3 |pages= 422–35 |year= 1997 |pmid= 9205114 |doi= 10.1006/geno.1997.4745
*cite journal | author=Fomitcheva J, Baker ME, Anderson E, "et al." |title=Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22664–71 |year= 1998 |pmid= 9712896 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Aziz N, Anderson E, Lee GY, Woo DD |title=Arrested testis development in the cpk mouse may be the result of abnormal steroid metabolism. |journal=Mol. Cell. Endocrinol. |volume=171 |issue= 1-2 |pages= 83–8 |year= 2001 |pmid= 11165015 |doi=
*cite journal | author=Kutsenko AS, Gizatullin RZ, Al-Amin AN, "et al." |title=NotI flanking sequences: a tool for gene discovery and verification of the human genome. |journal=Nucleic Acids Res. |volume=30 |issue= 14 |pages= 3163–70 |year= 2002 |pmid= 12136098 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Song D, Liu G, Luu-The V, "et al." |title=Expression of aromatase and 17beta-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer. An immunocytochemical study. |journal=J. Steroid Biochem. Mol. Biol. |volume=101 |issue= 2-3 |pages= 136–44 |year= 2006 |pmid= 16930994 |doi= 10.1016/j.jsbmb.2006.06.015
*cite journal | author=Villar J, Celay J, Alonso MM, "et al." |title=Transcriptional regulation of the human type 8 17beta-hydroxysteroid dehydrogenase gene by C/EBPbeta. |journal=J. Steroid Biochem. Mol. Biol. |volume=105 |issue= 1-5 |pages= 131–9 |year= 2007 |pmid= 17583490 |doi= 10.1016/j.jsbmb.2006.12.106

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