PFDN5

Prefoldin subunit 5, also known as PFDN5, is a human gene.cite web | title = Entrez Gene: PFDN5 prefoldin subunit 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5204| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described.cite web | title = Entrez Gene: PFDN5 prefoldin subunit 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5204| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Vainberg IE, Lewis SA, Rommelaere H, "et al." |title=Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin. |journal=Cell |volume=93 |issue= 5 |pages= 863–73 |year= 1998 |pmid= 9630229 |doi=
*cite journal | author=Mori K, Maeda Y, Kitaura H, "et al." |title=MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc. |journal=J. Biol. Chem. |volume=273 |issue= 45 |pages= 29794–800 |year= 1998 |pmid= 9792694 |doi=
*cite journal | author=Hansen WJ, Cowan NJ, Welch WJ |title=Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins. |journal=J. Cell Biol. |volume=145 |issue= 2 |pages= 265–77 |year= 1999 |pmid= 10209023 |doi=
*cite journal | author=Cowan NJ, Lewis SA |title=A chaperone with a hydrophilic surface. |journal=Nat. Struct. Biol. |volume=6 |issue= 11 |pages= 990–1 |year= 2002 |pmid= 10542082 |doi= 10.1038/14870
*cite journal | author=Rommelaere H, De Neve M, Neirynck K, "et al." |title=Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 41023–8 |year= 2001 |pmid= 11535601 |doi= 10.1074/jbc.M106591200
*cite journal | author=Fujioka Y, Taira T, Maeda Y, "et al." |title=MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer. |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 45137–44 |year= 2002 |pmid= 11567024 |doi= 10.1074/jbc.M106127200
*cite journal | author=Watanabe K, Ozaki T, Nakagawa T, "et al." |title=Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function. |journal=J. Biol. Chem. |volume=277 |issue= 17 |pages= 15113–23 |year= 2002 |pmid= 11844794 |doi= 10.1074/jbc.M111281200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Simons CT, Staes A, Rommelaere H, "et al." |title=Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding. |journal=J. Biol. Chem. |volume=279 |issue= 6 |pages= 4196–203 |year= 2004 |pmid= 14634002 |doi= 10.1074/jbc.M306053200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Bruneel A, Labas V, Mailloux A, "et al." |title=Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. |journal=Proteomics |volume=5 |issue= 15 |pages= 3876–84 |year= 2006 |pmid= 16130169 |doi= 10.1002/pmic.200401239
*cite journal | author=Hagio Y, Kimura Y, Taira T, "et al." |title=Distinct localizations and repression activities of MM-1 isoforms toward c-Myc. |journal=J. Cell. Biochem. |volume=97 |issue= 1 |pages= 145–55 |year= 2006 |pmid= 16173081 |doi= 10.1002/jcb.20619

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