CST8 (gene)

Cystatin 8 (cystatin-related epididymal specific), also known as CST8, is a human gene.cite web | title = Entrez Gene: CST8 cystatin 8 (cystatin-related epididymal specific)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10047| accessdate = ]

PBB_Summary
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summary_text = The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a protein similar to type 2 cystatins. The protein exhibits highly tissue-specific expression in the reproductive tract, suggesting implicit roles in reproduction. Alternative splicing identified in mouse is suggested in human based on EST evidence but the full-length nature of putative variants has not been determined.cite web | title = Entrez Gene: CST8 cystatin 8 (cystatin-related epididymal specific)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10047| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Brown WM, Dziegielewska KM |title=Friends and relations of the cystatin superfamily--new members and their evolution. |journal=Protein Sci. |volume=6 |issue= 1 |pages= 5–12 |year= 1997 |pmid= 9007972 |doi=
*cite journal | author=Ramachandran P, Boontheung P, Xie Y, "et al." |title=Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. |journal=J. Proteome Res. |volume=5 |issue= 6 |pages= 1493–503 |year= 2006 |pmid= 16740002 |doi= 10.1021/pr050492k
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wassler M, Syntin P, Sutton-Walsh HG, "et al." |title=Identification and characterization of cystatin-related epididymal spermatogenic protein in human spermatozoa: localization in the equatorial segment. |journal=Biol. Reprod. |volume=67 |issue= 3 |pages= 795–803 |year= 2003 |pmid= 12193387 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Cornwall GA, Hsia N, Sutton HG |title=Structure, alternative splicing and chromosomal localization of the cystatin-related epididymal spermatogenic gene. |journal=Biochem. J. |volume=340 ( Pt 1) |issue= |pages= 85–93 |year= 1999 |pmid= 10229662 |doi=
*cite journal | author=Thiesse M, Millar SJ, Dickinson DP |title=The human type 2 cystatin gene family consists of eight to nine members, with at least seven genes clustered at a single locus on human chromosome 20. |journal=DNA Cell Biol. |volume=13 |issue= 2 |pages= 97–116 |year= 1994 |pmid= 8179826 |doi=
*cite journal | author=Dickinson DP, Zhao Y, Thiesse M, Siciliano MJ |title=Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2. |journal=Genomics |volume=24 |issue= 1 |pages= 172–5 |year= 1995 |pmid= 7896273 |doi= 10.1006/geno.1994.1595
*cite journal | author=Dickinson DP, Thiesse M, Dempsey LD, Millar SJ |title=Genomic cloning, physical mapping, and expression of human type 2 cystatin genes. |journal=Crit. Rev. Oral Biol. Med. |volume=4 |issue= 3-4 |pages= 573–80 |year= 1993 |pmid= 7690606 |doi=
*cite journal | author=Saitoh E, Isemura S, Sanada K, "et al." |title=Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes. |journal=Biol. Chem. Hoppe-Seyler |volume=369 Suppl |issue= |pages= 191–7 |year= 1989 |pmid= 3202964 |doi=
*cite journal | author=Cornwall GA, Orgebin-Crist MC, Hann SR |title=The CRES gene: a unique testis-regulated gene related to the cystatin family is highly restricted in its expression to the proximal region of the mouse epididymis. |journal=Mol. Endocrinol. |volume=6 |issue= 10 |pages= 1653–64 |year= 1992 |pmid= 1280328 |doi=

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