LONP1

Lon peptidase 1, mitochondrial, also known as LONP1, is a human gene.cite web | title = Entrez Gene: LONP1 lon peptidase 1, mitochondrial| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9361| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a mitochondrial matrix protein in the Lon family of ATP-dependent proteases. A similar E. coli protein regulates gene expression by targeting specific regulatory proteins for degradation. This protein binds a specific sequence in the light and heavy chain promoters of the mitochondrial genome which are involved in regulation of DNA replication and transcription.cite web | title = Entrez Gene: LONP1 lon peptidase 1, mitochondrial| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9361| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lu B, Yadav S, Shah PG, "et al." |title=Roles for the human ATP-dependent Lon protease in mitochondrial DNA maintenance. |journal=J. Biol. Chem. |volume=282 |issue= 24 |pages= 17363–74 |year= 2007 |pmid= 17420247 |doi= 10.1074/jbc.M611540200
*cite journal | author=Bota DA, Ngo JK, Davies KJ |title=Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death. |journal=Free Radic. Biol. Med. |volume=38 |issue= 5 |pages= 665–77 |year= 2005 |pmid= 15683722 |doi= 10.1016/j.freeradbiomed.2004.11.017
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Liu T, Lu B, Lee I, "et al." |title=DNA and RNA binding by the mitochondrial lon protease is regulated by nucleotide and protein substrate. |journal=J. Biol. Chem. |volume=279 |issue= 14 |pages= 13902–10 |year= 2004 |pmid= 14739292 |doi= 10.1074/jbc.M309642200
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Lu B, Liu T, Crosby JA, "et al." |title=The ATP-dependent Lon protease of Mus musculus is a DNA-binding protein that is functionally conserved between yeast and mammals. |journal=Gene |volume=306 |issue= |pages= 45–55 |year= 2003 |pmid= 12657466 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Bota DA, Davies KJ |title=Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. |journal=Nat. Cell Biol. |volume=4 |issue= 9 |pages= 674–80 |year= 2002 |pmid= 12198491 |doi= 10.1038/ncb836
*cite journal | author=Hori O, Ichinoda F, Tamatani T, "et al." |title=Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease. |journal=J. Cell Biol. |volume=157 |issue= 7 |pages= 1151–60 |year= 2002 |pmid= 12082077 |doi= 10.1083/jcb.200108103
*cite journal | author=Fu GK, Markovitz DM |title=The human LON protease binds to mitochondrial promoters in a single-stranded, site-specific, strand-specific manner. |journal=Biochemistry |volume=37 |issue= 7 |pages= 1905–9 |year= 1998 |pmid= 9485316 |doi= 10.1021/bi970928c
*cite journal | author=Korenberg JR, Chen XN, Adams MD, Venter JC |title=Toward a cDNA map of the human genome. |journal=Genomics |volume=29 |issue= 2 |pages= 364–70 |year= 1996 |pmid= 8666383 |doi=
*cite journal | author=Wang N, Gottesman S, Willingham MC, "et al." |title=A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 23 |pages= 11247–51 |year= 1994 |pmid= 8248235 |doi=
*cite journal | author=Amerik AYu , Petukhova GV, Grigorenko VG, "et al." |title=Cloning and sequence analysis of cDNA for a human homolog of eubacterial ATP-dependent Lon proteases. |journal=FEBS Lett. |volume=340 |issue= 1-2 |pages= 25–8 |year= 1994 |pmid= 8119403 |doi=
*cite journal | author=Wang N, Maurizi MR, Emmert-Buck L, Gottesman MM |title=Synthesis, processing, and localization of human Lon protease. |journal=J. Biol. Chem. |volume=269 |issue= 46 |pages= 29308–13 |year= 1994 |pmid= 7961901 |doi=

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