TRIM63

Tripartite motif-containing 63, also known as TRIM63, is a human gene.cite web | title = Entrez Gene: TRIM63 tripartite motif-containing 63| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84676| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.cite web | title = Entrez Gene: TRIM63 tripartite motif-containing 63| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84676| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Centner T, Yano J, Kimura E, "et al." |title=Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. |journal=J. Mol. Biol. |volume=306 |issue= 4 |pages= 717–26 |year= 2001 |pmid= 11243782 |doi= 10.1006/jmbi.2001.4448
*cite journal | author=Dai KS, Liew CC |title=A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23992–9 |year= 2001 |pmid= 11283016 |doi= 10.1074/jbc.M011208200
*cite journal | author=Bodine SC, Latres E, Baumhueter S, "et al." |title=Identification of ubiquitin ligases required for skeletal muscle atrophy. |journal=Science |volume=294 |issue= 5547 |pages= 1704–8 |year= 2001 |pmid= 11679633 |doi= 10.1126/science.1065874
*cite journal | author=McElhinny AS, Kakinuma K, Sorimachi H, "et al." |title=Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. |journal=J. Cell Biol. |volume=157 |issue= 1 |pages= 125–36 |year= 2002 |pmid= 11927605 |doi= 10.1083/jcb.200108089
*cite journal | author=Wistow G, Bernstein SL, Ray S, "et al." |title=Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium. |journal=Mol. Vis. |volume=8 |issue= |pages= 185–95 |year= 2002 |pmid= 12107412 |doi=
*cite journal | author=Pizon V, Iakovenko A, Van Der Ven PF, "et al." |title=Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein. |journal=J. Cell. Sci. |volume=115 |issue= Pt 23 |pages= 4469–82 |year= 2003 |pmid= 12414993 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kedar V, McDonough H, Arya R, "et al." |title=Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 52 |pages= 18135–40 |year= 2005 |pmid= 15601779 |doi= 10.1073/pnas.0404341102
*cite journal | author=Witt SH, Granzier H, Witt CC, Labeit S |title=MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination. |journal=J. Mol. Biol. |volume=350 |issue= 4 |pages= 713–22 |year= 2005 |pmid= 15967462 |doi= 10.1016/j.jmb.2005.05.021
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Doucet M, Russell AP, Léger B, "et al." |title=Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease. |journal=Am. J. Respir. Crit. Care Med. |volume=176 |issue= 3 |pages= 261–9 |year= 2007 |pmid= 17478621 |doi= 10.1164/rccm.200605-704OC

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