MAP2K1IP1

Mitogen-activated protein kinase kinase 1 interacting protein 1, also known as MAP2K1IP1, is a human gene.cite web | title = Entrez Gene: MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8649| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene was identified as an interacting protein that binds specifically to MAP kinase kinase MAP2K1/MEK1 and to MAP kinase MAPK2/ERK1. This protein enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.cite web | title = Entrez Gene: MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8649| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Schaeffer HJ, Catling AD, Eblen ST, "et al." |title=MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. |journal=Science |volume=281 |issue= 5383 |pages= 1668–71 |year= 1998 |pmid= 9733512 |doi=
*cite journal | author=Okabe S, Tauchi T, Morita H, "et al." |title=Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway. |journal=Exp. Hematol. |volume=27 |issue= 10 |pages= 1542–7 |year= 1999 |pmid= 10517496 |doi=
*cite journal | author=Wunderlich W, Fialka I, Teis D, "et al." |title=A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment. |journal=J. Cell Biol. |volume=152 |issue= 4 |pages= 765–76 |year= 2001 |pmid= 11266467 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Teis D, Wunderlich W, Huber LA |title=Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. |journal=Dev. Cell |volume=3 |issue= 6 |pages= 803–14 |year= 2003 |pmid= 12479806 |doi=
*cite journal | author=Channavajhala PL, Wu L, Cuozzo JW, "et al." |title=Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 47089–97 |year= 2004 |pmid= 12975377 |doi= 10.1074/jbc.M306002200
*cite journal | author=Paces-Fessy M, Boucher D, Petit E, "et al." |title=The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins. |journal=Biochem. J. |volume=378 |issue= Pt 2 |pages= 353–62 |year= 2004 |pmid= 14611647 |doi= 10.1042/BJ20030786
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Lunin VV, Munger C, Wagner J, "et al." |title=The structure of the MAPK scaffold, MP1, bound to its partner, p14. A complex with a critical role in endosomal map kinase signaling. |journal=J. Biol. Chem. |volume=279 |issue= 22 |pages= 23422–30 |year= 2004 |pmid= 15016825 |doi= 10.1074/jbc.M401648200
*cite journal | author=Vomastek T, Schaeffer HJ, Tarcsafalvi A, "et al." |title=Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 18 |pages= 6981–6 |year= 2004 |pmid= 15118098 |doi= 10.1073/pnas.0305894101
*cite journal | author=Kurzbauer R, Teis D, de Araujo ME, "et al." |title=Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 30 |pages= 10984–9 |year= 2004 |pmid= 15263099 |doi= 10.1073/pnas.0403435101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Sharma C, Vomastek T, Tarcsafalvi A, "et al." |title=MEK partner 1 (MP1): regulation of oligomerization in MAP kinase signaling. |journal=J. Cell. Biochem. |volume=94 |issue= 4 |pages= 708–19 |year= 2005 |pmid= 15547943 |doi= 10.1002/jcb.20344
*cite journal | author=Pullikuth A, McKinnon E, Schaeffer HJ, Catling AD |title=The MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals. |journal=Mol. Cell. Biol. |volume=25 |issue= 12 |pages= 5119–33 |year= 2005 |pmid= 15923628 |doi= 10.1128/MCB.25.12.5119-5133.2005
*cite journal | author=Villegas SN, Njaine B, Linden R, Carri NG |title=Glial-derived neurotrophic factor (GDNF) prevents ethanol (EtOH) induced B92 glial cell death by both PI3K/AKT and MEK/ERK signaling pathways. |journal=Brain Res. Bull. |volume=71 |issue= 1-3 |pages= 116–26 |year= 2007 |pmid= 17113937 |doi= 10.1016/j.brainresbull.2006.08.014
*cite journal | author=Teis D, Taub N, Kurzbauer R, "et al." |title=p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. |journal=J. Cell Biol. |volume=175 |issue= 6 |pages= 861–8 |year= 2007 |pmid= 17178906 |doi= 10.1083/jcb.200607025
*cite journal | author=Brahma A, Dalby KN |title=Regulation of protein phosphorylation within the MKK1-ERK2 complex by MP1 and the MP1*P14 heterodimer. |journal=Arch. Biochem. Biophys. |volume=460 |issue= 1 |pages= 85–91 |year= 2007 |pmid= 17254543 |doi= 10.1016/j.abb.2006.11.031
*cite journal | author=Vomastek T, Iwanicki MP, Schaeffer HJ, "et al." |title=RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility. |journal=Mol. Cell. Biol. |volume=27 |issue= 23 |pages= 8296–305 |year= 2007 |pmid= 17908799 |doi= 10.1128/MCB.00598-07

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