SPAG1

Sperm associated antigen 1, also known as SPAG1, is a human gene.cite web | title = Entrez Gene: SPAG1 sperm associated antigen 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6674| accessdate = ]

PBB_Summary
section_title =
summary_text = The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.cite web | title = Entrez Gene: SPAG1 sperm associated antigen 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6674| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schuler GD, Boguski MS, Stewart EA, "et al." |title=A gene map of the human genome. |journal=Science |volume=274 |issue= 5287 |pages= 540–6 |year= 1996 |pmid= 8849440 |doi=
*cite journal | author=Diekman AB, Herr JC |title=Sperm antigens and their use in the development of an immunocontraceptive. |journal=Am. J. Reprod. Immunol. |volume=37 |issue= 1 |pages= 111–7 |year= 1997 |pmid= 9138444 |doi=
*cite journal | author=Zhang ML, Wang LF, Miao SY, Koide SS |title=Isolation and sequencing of the cDNA encoding the 75-kD human sperm protein related to infertility. |journal=Chin. Med. J. |volume=105 |issue= 12 |pages= 998–1003 |year= 1993 |pmid= 1299558 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Takaishi M, Huh N |title=A tetratricopeptide repeat-containing protein gene, tpis, whose expression is induced with differentiation of spermatogenic cells. |journal=Biochem. Biophys. Res. Commun. |volume=264 |issue= 1 |pages= 81–5 |year= 1999 |pmid= 10527845 |doi= 10.1006/bbrc.1999.1477
*cite journal | author=Lin W, Zhou X, Zhang M, "et al." |title=Expression and function of the HSD-3.8 gene encoding a testis-specific protein. |journal=Mol. Hum. Reprod. |volume=7 |issue= 9 |pages= 811–8 |year= 2001 |pmid= 11517287 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ficarro S, Chertihin O, Westbrook VA, "et al." |title=Phosphoproteome analysis of capacitated human sperm. Evidence of tyrosine phosphorylation of a kinase-anchoring protein 3 and valosin-containing protein/p97 during capacitation. |journal=J. Biol. Chem. |volume=278 |issue= 13 |pages= 11579–89 |year= 2003 |pmid= 12509440 |doi= 10.1074/jbc.M202325200
*cite journal | author=Kanazawa R, Komori S, Sakata K, "et al." |title=Isolation and characterization of a human sperm antigen gene h-Sp-1. |journal=Int. J. Androl. |volume=26 |issue= 4 |pages= 226–35 |year= 2004 |pmid= 12846798 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Liu N, Qiao Y, Cai C, "et al." |title=A sperm component, HSD-3.8 (SPAG1), interacts with G-protein beta 1 subunit and activates extracellular signal-regulated kinases (ERK). |journal=Front. Biosci. |volume=11 |issue= |pages= 1679–89 |year= 2006 |pmid= 16368546 |doi=
*cite journal | author=Neesse A, Gangeswaran R, Luettges J, "et al." |title=Sperm-associated antigen 1 is expressed early in pancreatic tumorigenesis and promotes motility of cancer cells. |journal=Oncogene |volume=26 |issue= 11 |pages= 1533–45 |year= 2007 |pmid= 16983343 |doi= 10.1038/sj.onc.1209961

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes