BFSP1

Beaded filament structural protein 1, filensin, also known as BFSP1, is a human gene.cite web | title = Entrez Gene: BFSP1 beaded filament structural protein 1, filensin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=631| accessdate = ]

PBB_Summary
section_title =
summary_text = More than 99% of the vertebrate ocular lens is comprised of terminally differentiated lens fiber cells. Two lens-specific intermediate filament-like proteins, CP49 (also known as phakinin) and the protein product of this gene, filensin (or CP115), are expressed only after fiber cell differentiation has begun. Both proteins are found in a structurally unique cytoskeletal element that is referred to as the beaded filament (BF).cite web | title = Entrez Gene: BFSP1 beaded filament structural protein 1, filensin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=631| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Brunkener M, Georgatos SD |title=Membrane-binding properties of filensin, a cytoskeletal protein of the lens fiber cells. |journal=J. Cell. Sci. |volume=103 ( Pt 3) |issue= |pages= 709–18 |year= 1993 |pmid= 1478967 |doi=
*cite journal | author=Merdes A, Brunkener M, Horstmann H, Georgatos SD |title=Filensin: a new vimentin-binding, polymerization-competent, and membrane-associated protein of the lens fiber cell. |journal=J. Cell Biol. |volume=115 |issue= 2 |pages= 397–410 |year= 1991 |pmid= 1918147 |doi=
*cite journal | author=Merdes A, Gounari F, Georgatos SD |title=The 47-kD lens-specific protein phakinin is a tailless intermediate filament protein and an assembly partner of filensin. |journal=J. Cell Biol. |volume=123 |issue= 6 Pt 1 |pages= 1507–16 |year= 1994 |pmid= 7504675 |doi=
*cite journal | author=Sandilands A, Prescott AR, Carter JM, "et al." |title=Vimentin and CP49/filensin form distinct networks in the lens which are independently modulated during lens fibre cell differentiation. |journal=J. Cell. Sci. |volume=108 ( Pt 4) |issue= |pages= 1397–406 |year= 1995 |pmid= 7615661 |doi=
*cite journal | author=Hess JF, Casselman JT, FitzGerald PG |title=cDNA analysis of the 49 kDa lens fiber cell cytoskeletal protein: a new, lens-specific member of the intermediate filament family? |journal=Curr. Eye Res. |volume=12 |issue= 1 |pages= 77–88 |year= 1993 |pmid= 7679620 |doi=
*cite journal | author=Hess JF, Casselman JT, FitzGerald PG |title=Chromosomal locations of the genes for the beaded filament proteins CP 115 and CP 47. |journal=Curr. Eye Res. |volume=14 |issue= 1 |pages= 11–8 |year= 1995 |pmid= 7720401 |doi=
*cite journal | author=Carter JM, Hutcheson AM, Quinlan RA |title=In vitro studies on the assembly properties of the lens proteins CP49, CP115: coassembly with alpha-crystallin but not with vimentin. |journal=Exp. Eye Res. |volume=60 |issue= 2 |pages= 181–92 |year= 1995 |pmid= 7781747 |doi=
*cite journal | author=Hess JF, Casselman JT, Kong AP, FitzGerald PG |title=Primary sequence, secondary structure, gene structure, and assembly properties suggests that the lens-specific cytoskeletal protein filensin represents a novel class of intermediate filament protein. |journal=Exp. Eye Res. |volume=66 |issue= 5 |pages= 625–44 |year= 1998 |pmid= 9628810 |doi= 10.1006/exer.1998.0478
*cite journal | author=Rendtorff ND, Hansen C, Silahtaroglu A, "et al." |title=Isolation of the human beaded-filament structural protein 1 gene (BFSP1) and assignment to chromosome 20p11.23-p12.1. |journal=Genomics |volume=53 |issue= 1 |pages= 114–6 |year= 1998 |pmid= 9787085 |doi= 10.1006/geno.1998.5478
*cite journal | author=Yamada K, Tomita H, Yoshiura K, "et al." |title=An autosomal dominant posterior polar cataract locus maps to human chromosome 20p12-q12. |journal=Eur. J. Hum. Genet. |volume=8 |issue= 7 |pages= 535–9 |year= 2000 |pmid= 10909854 |doi= 10.1038/sj.ejhg.5200485
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ramachandran RD, Perumalsamy V, Hejtmancik JF |title=Autosomal recessive juvenile onset cataract associated with mutation in BFSP1. |journal=Hum. Genet. |volume=121 |issue= 3-4 |pages= 475–82 |year= 2007 |pmid= 17225135 |doi= 10.1007/s00439-006-0319-6

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