PREX1

Phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1, also known as PREX1, is a human gene.cite web | title = Entrez Gene: PREX1 phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57580| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins.cite web | title = Entrez Gene: PREX1 phosphatidylinositol 3,4,5-trisphosphate-dependent RAC exchanger 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57580| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Nagase T, Kikuno R, Ishikawa KI, "et al." |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65–73 |year= 2000 |pmid= 10718198 |doi=
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Fossey SC, Mychaleckyj JC, Pendleton JK, "et al." |title=A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. |journal=Genomics |volume=76 |issue= 1-3 |pages= 45–57 |year= 2001 |pmid= 11549316 |doi= 10.1006/geno.2001.6584
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Welch HC, Coadwell WJ, Ellson CD, "et al." |title=P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac. |journal=Cell |volume=108 |issue= 6 |pages= 809–21 |year= 2002 |pmid= 11955434 |doi=
*cite journal | author=Weiner OD |title=Rac activation: P-Rex1 - a convergence point for PIP(3) and Gbetagamma? |journal=Curr. Biol. |volume=12 |issue= 12 |pages= R429–31 |year= 2002 |pmid= 12123595 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hill K, Krugmann S, Andrews SR, "et al." |title=Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits. |journal=J. Biol. Chem. |volume=280 |issue= 6 |pages= 4166–73 |year= 2005 |pmid= 15545267 |doi= 10.1074/jbc.M411262200
*cite journal | author=Mayeenuddin LH, Garrison JC |title=Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity. |journal=J. Biol. Chem. |volume=281 |issue= 4 |pages= 1921–8 |year= 2006 |pmid= 16301320 |doi= 10.1074/jbc.M506035200
*cite journal | author=Zhao T, Nalbant P, Hoshino M, "et al." |title=Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function. |journal=J. Leukoc. Biol. |volume=81 |issue= 4 |pages= 1127–36 |year= 2007 |pmid= 17227822 |doi= 10.1189/jlb.0406251
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134
*cite journal | author=Hernández-Negrete I, Carretero-Ortega J, Rosenfeldt H, "et al." |title=P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration. |journal=J. Biol. Chem. |volume=282 |issue= 32 |pages= 23708–15 |year= 2007 |pmid= 17565979 |doi= 10.1074/jbc.M703771200
*cite journal | author=Barber MA, Donald S, Thelen S, "et al." |title=Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase. |journal=J. Biol. Chem. |volume=282 |issue= 41 |pages= 29967–76 |year= 2007 |pmid= 17698854 |doi= 10.1074/jbc.M701877200

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