MSRA (gene)

Methionine sulfoxide reductase A, also known as MSRA, is a human gene.cite web | title = Entrez Gene: MSRA methionine sulfoxide reductase A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4482| accessdate = ]

PBB_Summary
section_title =
summary_text = This protein is ubiquitous and highly conserved. It carries out the enzymatic reduction of methionine sulfoxide to methionine. Human and animal studies have shown the highest levels of expression in kidney and nervous tissue. Its proposed function is the repair of oxidative damage to proteins to restore biological activity.cite web | title = Entrez Gene: MSRA methionine sulfoxide reductase A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4482| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hansel A, Heinemann SH, Hoshi T |title=Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation. |journal=Biochim. Biophys. Acta |volume=1703 |issue= 2 |pages= 239–47 |year= 2005 |pmid= 15680232 |doi= 10.1016/j.bbapap.2004.09.010
*cite journal | author=Moskovitz J, Jenkins NA, Gilbert DJ, "et al." |title=Chromosomal localization of the mammalian peptide-methionine sulfoxide reductase gene and its differential expression in various tissues. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 8 |pages= 3205–8 |year= 1996 |pmid= 8622914 |doi=
*cite journal | author=Kuschel L, Hansel A, Schönherr R, "et al." |title=Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA). |journal=FEBS Lett. |volume=456 |issue= 1 |pages= 17–21 |year= 1999 |pmid= 10452521 |doi=
*cite journal | author=Hansel A, Kuschel L, Hehl S, "et al." |title=Mitochondrial targeting of the human peptide methionine sulfoxide reductase (MSRA), an enzyme involved in the repair of oxidized proteins. |journal=FASEB J. |volume=16 |issue= 8 |pages= 911–3 |year= 2002 |pmid= 12039877 |doi= 10.1096/fj.01-0737fje
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Vougier S, Mary J, Friguet B |title=Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells. |journal=Biochem. J. |volume=373 |issue= Pt 2 |pages= 531–7 |year= 2003 |pmid= 12693988 |doi= 10.1042/BJ20030443
*cite journal | author=Picot CR, Perichon M, Cintrat JC, "et al." |title=The peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblasts. |journal=FEBS Lett. |volume=558 |issue= 1-3 |pages= 74–8 |year= 2004 |pmid= 14759519 |doi= 10.1016/S0014-5793(03)01530-8
*cite journal | author=Kantorow M, Hawse JR, Cowell TL, "et al." |title=Methionine sulfoxide reductase A is important for lens cell viability and resistance to oxidative stress. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 26 |pages= 9654–9 |year= 2004 |pmid= 15199188 |doi= 10.1073/pnas.0403532101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=De Luca A, Sacchetta P, Di Ilio C, Favaloro B |title=Identification and analysis of the promoter region of the human methionine sulphoxide reductase A gene. |journal=Biochem. J. |volume=393 |issue= Pt 1 |pages= 321–9 |year= 2006 |pmid= 16162094 |doi= 10.1042/BJ20050973
*cite journal | author=Picot CR, Petropoulos I, Perichon M, "et al." |title=Overexpression of MsrA protects WI-38 SV40 human fibroblasts against H2O2-mediated oxidative stress. |journal=Free Radic. Biol. Med. |volume=39 |issue= 10 |pages= 1332–41 |year= 2006 |pmid= 16257642 |doi= 10.1016/j.freeradbiomed.2005.06.017
*cite journal | author=Lee JW, Gordiyenko NV, Marchetti M, "et al." |title=Gene structure, localization and role in oxidative stress of methionine sulfoxide reductase A (MSRA) in the monkey retina. |journal=Exp. Eye Res. |volume=82 |issue= 5 |pages= 816–27 |year= 2006 |pmid= 16364291 |doi= 10.1016/j.exer.2005.10.003
*cite journal | author=Schallreuter KU, Rübsam K, Chavan B, "et al." |title=Functioning methionine sulfoxide reductases A and B are present in human epidermal melanocytes in the cytosol and in the nucleus. |journal=Biochem. Biophys. Res. Commun. |volume=342 |issue= 1 |pages= 145–52 |year= 2006 |pmid= 16480945 |doi= 10.1016/j.bbrc.2006.01.124
*cite journal | author=Lei KF, Wang YF, Zhu XQ, "et al." |title=Identification of MSRA gene on chromosome 8p as a candidate metastasis suppressor for human hepatitis B virus-positive hepatocellular carcinoma. |journal=BMC Cancer |volume=7 |issue= |pages= 172 |year= 2007 |pmid= 17784942 |doi= 10.1186/1471-2407-7-172

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