SEC61A1

Sec61 alpha 1 subunit (S. cerevisiae), also known as SEC61A1, is a human gene.cite web | title = Entrez Gene: SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29927| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits.cite web | title = Entrez Gene: SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29927| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wiertz EJ, Tortorella D, Bogyo M, "et al." |title=Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. |journal=Nature |volume=384 |issue= 6608 |pages= 432–8 |year= 1997 |pmid= 8945469 |doi= 10.1038/384432a0
*cite journal | author=Knight BC, High S |title=Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex. |journal=Biochem. J. |volume=331 ( Pt 1) |issue= |pages= 161–7 |year= 1998 |pmid= 9512475 |doi=
*cite journal | author=Chen Y, Le Cahérec F, Chuck SL |title=Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex. |journal=J. Biol. Chem. |volume=273 |issue= 19 |pages= 11887–94 |year= 1998 |pmid= 9565615 |doi=
*cite journal | author=Bebök Z, Mazzochi C, King SA, "et al." |title=The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary. |journal=J. Biol. Chem. |volume=273 |issue= 45 |pages= 29873–8 |year= 1998 |pmid= 9792704 |doi=
*cite journal | author=Greenfield JJ, High S |title=The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment. |journal=J. Cell. Sci. |volume=112 ( Pt 10) |issue= |pages= 1477–86 |year= 1999 |pmid= 10212142 |doi=
*cite journal | author=Yamaguchi A, Hori O, Stern DM, "et al." |title=Stress-associated endoplasmic reticulum protein 1 (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes membrane proteins during stress and facilitates subsequent glycosylation. |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1195–204 |year= 2000 |pmid= 10601334 |doi=
*cite journal | author=Petaja-Repo UE, Hogue M, Laperriere A, "et al." |title=Newly synthesized human delta opioid receptors retained in the endoplasmic reticulum are retrotranslocated to the cytosol, deglycosylated, ubiquitinated, and degraded by the proteasome. |journal=J. Biol. Chem. |volume=276 |issue= 6 |pages= 4416–23 |year= 2001 |pmid= 11054417 |doi= 10.1074/jbc.M007151200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Otsuki T, Ota T, Nishikawa T, "et al." |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes