FBXO4

F-box protein 4, also known as FBXO4, is a human gene.cite web | title = Entrez Gene: FBXO4 F-box protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26272| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.cite web | title = Entrez Gene: FBXO4 F-box protein 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26272| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Cenciarelli C, Chiaur DS, Guardavaccaro D, "et al." |title=Identification of a family of human F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1177–9 |year= 1999 |pmid= 10531035 |doi= 10.1016/S0960-9822(00)80020-2
*cite journal | author=Winston JT, Koepp DM, Zhu C, "et al." |title=A family of mammalian F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180–2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4
*cite journal | author=Chiaur DS, Murthy S, Cenciarelli C, "et al." |title=Five human genes encoding F-box proteins: chromosome mapping and analysis in human tumors. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 3-4 |pages= 255–8 |year= 2000 |pmid= 10828603 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Jin J, Cardozo T, Lovering RC, "et al." |title=Systematic analysis and nomenclature of mammalian F-box proteins. |journal=Genes Dev. |volume=18 |issue= 21 |pages= 2573–80 |year= 2005 |pmid= 15520277 |doi= 10.1101/gad.1255304
*cite journal | author=Lee TH, Perrem K, Harper JW, "et al." |title=The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance. |journal=J. Biol. Chem. |volume=281 |issue= 2 |pages= 759–68 |year= 2006 |pmid= 16275645 |doi= 10.1074/jbc.M509855200
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Liu Y, Hedvat CV, Mao S, "et al." |title=The ETS protein MEF is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCFSkp2. |journal=Mol. Cell. Biol. |volume=26 |issue= 8 |pages= 3114–23 |year= 2006 |pmid= 16581786 |doi= 10.1128/MCB.26.8.3114-3123.2006
*cite journal | author=Lin DI, Barbash O, Kumar KG, "et al." |title=Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. |journal=Mol. Cell |volume=24 |issue= 3 |pages= 355–66 |year= 2006 |pmid= 17081987 |doi= 10.1016/j.molcel.2006.09.007
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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