FGF3 (gene)

Fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog), also known as FGF3, is a human gene.cite web | title = Entrez Gene: FGF3 fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2248| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.cite web | title = Entrez Gene: FGF3 fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2248| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Represa J, León Y, Miner C, Giraldez F |title=The int-2 proto-oncogene is responsible for induction of the inner ear. |journal=Nature |volume=353 |issue= 6344 |pages= 561–3 |year= 1991 |pmid= 1922362 |doi= 10.1038/353561a0
*cite journal | author=Brookes S, Smith R, Casey G, "et al." |title=Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells. |journal=Oncogene |volume=4 |issue= 4 |pages= 429–36 |year= 1989 |pmid= 2470007 |doi=
*cite journal | author=Casey G, Smith R, McGillivray D, "et al." |title=Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene. |journal=Mol. Cell. Biol. |volume=6 |issue= 2 |pages= 502–10 |year= 1987 |pmid= 3023852 |doi=
*cite journal | author=Mansour SL, Goddard JM, Capecchi MR |title=Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear. |journal=Development |volume=117 |issue= 1 |pages= 13–28 |year= 1993 |pmid= 8223243 |doi=
*cite journal | author=Ornitz DM, Xu J, Colvin JS, "et al." |title=Receptor specificity of the fibroblast growth factor family. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15292–7 |year= 1996 |pmid= 8663044 |doi=
*cite journal | author=Galdemard C, Yamagata H, Brison O, Lavialle C |title=Regulation of FGF-3 gene expression in tumorigenic and non-tumorigenic clones of a human colon carcinoma cell line. |journal=J. Biol. Chem. |volume=275 |issue= 23 |pages= 17364–73 |year= 2000 |pmid= 10749884 |doi= 10.1074/jbc.M909316199
*cite journal | author=Reimers K, Antoine M, Zapatka M, "et al." |title=NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth. |journal=Mol. Cell. Biol. |volume=21 |issue= 15 |pages= 4996–5007 |year= 2001 |pmid= 11438656 |doi= 10.1128/MCB.21.15.4996-5007.2001
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Popovici C, Conchonaud F, Birnbaum D, Roubin R |title=Functional phylogeny relates LET-756 to fibroblast growth factor 9. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40146–52 |year= 2004 |pmid= 15199049 |doi= 10.1074/jbc.M405795200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Antoine M, Reimers K, Wirz W, "et al." |title=Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2. |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 2 |pages= 1248–55 |year= 2006 |pmid= 16263090 |doi= 10.1016/j.bbrc.2005.10.079
*cite journal | author=Tekin M, Hişmi BO, Fitoz S, "et al." |title=Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia. |journal=Am. J. Hum. Genet. |volume=80 |issue= 2 |pages= 338–44 |year= 2007 |pmid= 17236138 |doi= 10.1086/510920
*cite journal | author=Riley BM, Mansilla MA, Ma J, "et al." |title=Impaired FGF signaling contributes to cleft lip and palate. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 11 |pages= 4512–7 |year= 2007 |pmid= 17360555 |doi= 10.1073/pnas.0607956104

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