IL1RAPL1

Interleukin 1 receptor accessory protein-like 1, also known as IL1RAPL1, is a human gene.cite web | title = Entrez Gene: IL1RAPL1 interleukin 1 receptor accessory protein-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11141| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the interleukin 1 receptor family and is similar to the interleukin 1 accessory proteins. It is most closely related to interleukin 1 receptor accessory protein-like 2 (IL1RAPL2). This gene and IL1RAPL2 are located at a region on chromosome X that is associated with X-linked non-syndromic mental retardation. Deletions and mutations in this gene were found in patients with mental retardation. This gene is expressed at a high level in post-natal brain structures involved in the hippocampal memory system, which suggests a specialized role in the physiological processes underlying memory and learning abilities.cite web | title = Entrez Gene: IL1RAPL1 interleukin 1 receptor accessory protein-like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11141| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kozák L, Chiurazzi P, Genuardi M, "et al." |title=Mapping of a gene for non-specific X linked mental retardation: evidence for linkage to chromosomal region Xp21.1-Xp22.3. |journal=J. Med. Genet. |volume=30 |issue= 10 |pages= 866–9 |year= 1993 |pmid= 8230164 |doi=
*cite journal | author=Tranebjaerg L, Lubs HA, Borghgraef M, "et al." |title=Seventh International Workshop on the Fragile X and X-linked Mental Retardation. |journal=Am. J. Med. Genet. |volume=64 |issue= 1 |pages= 1–14 |year= 1996 |pmid= 8826442 |doi= 10.1002/(SICI)1096-8628(19960712)64:1<1::AID-AJMG1>3.0.CO;2-Z |doilabel=10.1002/(SICI)1096-8628(19960712)64:11::AID-AJMG13.0.CO;2-Z
*cite journal | author=Liu C, Chalmers D, Maki R, De Souza EB |title=Rat homolog of mouse interleukin-1 receptor accessory protein: cloning, localization and modulation studies. |journal=J. Neuroimmunol. |volume=66 |issue= 1-2 |pages= 41–8 |year= 1996 |pmid= 8964912 |doi=
*cite journal | author=Carrié A, Jun L, Bienvenu T, "et al." |title=A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation. |journal=Nat. Genet. |volume=23 |issue= 1 |pages= 25–31 |year= 1999 |pmid= 10471494 |doi= 10.1038/12623
*cite journal | author=Jin H, Gardner RJ, Viswesvaraiah R, "et al." |title=Two novel members of the interleukin-1 receptor gene family, one deleted in Xp22.1-Xp21.3 mental retardation. |journal=Eur. J. Hum. Genet. |volume=8 |issue= 2 |pages= 87–94 |year= 2000 |pmid= 10757639 |doi= 10.1038/sj.ejhg.5200415
*cite journal | author=Born TL, Smith DE, Garka KE, "et al." |title=Identification and characterization of two members of a novel class of the interleukin-1 receptor (IL-1R) family. Delineation of a new class of IL-1R-related proteins based on signaling. |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 29946–54 |year= 2000 |pmid= 10882729 |doi= 10.1074/jbc.M004077200
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kitano T, Schwarz C, Nickel B, Pääbo S |title=Gene diversity patterns at 10 X-chromosomal loci in humans and chimpanzees. |journal=Mol. Biol. Evol. |volume=20 |issue= 8 |pages= 1281–9 |year= 2004 |pmid= 12777533 |doi= 10.1093/molbev/msg134
*cite journal | author=Bahi N, Friocourt G, Carrié A, "et al." |title=IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis. |journal=Hum. Mol. Genet. |volume=12 |issue= 12 |pages= 1415–25 |year= 2004 |pmid= 12783849 |doi=
*cite journal | author=Khan JA, Brint EK, O'Neill LA, Tong L |title=Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL. |journal=J. Biol. Chem. |volume=279 |issue= 30 |pages= 31664–70 |year= 2004 |pmid= 15123616 |doi= 10.1074/jbc.M403434200
*cite journal | author=Zhang YH, Huang BL, Niakan KK, "et al." |title=IL1RAPL1 is associated with mental retardation in patients with complex glycerol kinase deficiency who have deletions extending telomeric of DAX1. |journal=Hum. Mutat. |volume=24 |issue= 3 |pages= 273 |year= 2005 |pmid= 15300857 |doi= 10.1002/humu.9269
*cite journal | author=Tabolacci E, Pomponi MG, Pietrobono R, "et al." |title=A truncating mutation in the IL1RAPL1 gene is responsible for X-linked mental retardation in the MRX21 family. |journal=Am. J. Med. Genet. A |volume=140 |issue= 5 |pages= 482–7 |year= 2006 |pmid= 16470793 |doi= 10.1002/ajmg.a.31107

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