CPSF4

Cleavage and polyadenylation specific factor 4, 30kDa, also known as CPSF4, is a human gene.cite web | title = Entrez Gene: CPSF4 cleavage and polyadenylation specific factor 4, 30kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10898| accessdate = ]

PBB_Summary
section_title =
summary_text = Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.cite web | title = Entrez Gene: CPSF4 cleavage and polyadenylation specific factor 4, 30kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10898| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Jenny A, Hauri HP, Keller W |title=Characterization of cleavage and polyadenylation specificity factor and cloning of its 100-kilodalton subunit. |journal=Mol. Cell. Biol. |volume=14 |issue= 12 |pages= 8183–90 |year= 1994 |pmid= 7969155 |doi=
*cite journal | author=Thuresson AC, Aström J, Aström A, "et al." |title=Multiple forms of poly(A) polymerases in human cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 3 |pages= 979–83 |year= 1994 |pmid= 8302877 |doi=
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=McCracken S, Fong N, Yankulov K, "et al." |title=The C-terminal domain of RNA polymerase II couples mRNA processing to transcription. |journal=Nature |volume=385 |issue= 6614 |pages= 357–61 |year= 1997 |pmid= 9002523 |doi= 10.1038/385357a0
*cite journal | author=Barabino SM, Hübner W, Jenny A, "et al." |title=The 30-kD subunit of mammalian cleavage and polyadenylation specificity factor and its yeast homolog are RNA-binding zinc finger proteins. |journal=Genes Dev. |volume=11 |issue= 13 |pages= 1703–16 |year= 1997 |pmid= 9224719 |doi=
*cite journal | author=Nemeroff ME, Barabino SM, Li Y, "et al." |title=Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs. |journal=Mol. Cell |volume=1 |issue= 7 |pages= 991–1000 |year= 1998 |pmid= 9651582 |doi=
*cite journal | author=de Vries H, Rüegsegger U, Hübner W, "et al." |title=Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. |journal=EMBO J. |volume=19 |issue= 21 |pages= 5895–904 |year= 2000 |pmid= 11060040 |doi= 10.1093/emboj/19.21.5895
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Scherer SW, Cheung J, MacDonald JR, "et al." |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423
*cite journal | author=Kaufmann I, Martin G, Friedlein A, "et al." |title=Human Fip1 is a subunit of CPSF that binds to U-rich RNA elements and stimulates poly(A) polymerase. |journal=EMBO J. |volume=23 |issue= 3 |pages= 616–26 |year= 2005 |pmid= 14749727 |doi= 10.1038/sj.emboj.7600070
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Oh JH, Yang JO, Hahn Y, "et al." |title=Transcriptome analysis of human gastric cancer. |journal=Mamm. Genome |volume=16 |issue= 12 |pages= 942–54 |year= 2006 |pmid= 16341674 |doi= 10.1007/s00335-005-0075-2
*cite journal | author=Twu KY, Kuo RL, Marklund J, Krug RM |title=The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells. |journal=J. Virol. |volume=81 |issue= 15 |pages= 8112–21 |year= 2007 |pmid= 17522219 |doi= 10.1128/JVI.00006-07

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes