SEP15

15 kDa selenoprotein, also known as SEP15, is a human gene.cite web | title = Entrez Gene: SEP15 15 kDa selenoprotein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9403| accessdate = ]

PBB_Summary
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summary_text = This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies in mouse suggest that this selenoprotein may have redox function and may be involved in the quality control of protein folding. This gene is localized on chromosome 1p31, a genetic locus commonly mutated or deleted in human cancers. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.cite web | title = Entrez Gene: SEP15 15 kDa selenoprotein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9403| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Gladyshev VN, Jeang KT, Wootton JC, Hatfield DL |title=A new human selenium-containing protein. Purification, characterization, and cDNA sequence. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 8910–5 |year= 1998 |pmid= 9535873 |doi=
*cite journal | author=Kumaraswamy E, Malykh A, Korotkov KV, "et al." |title=Structure-expression relationships of the 15-kDa selenoprotein gene. Possible role of the protein in cancer etiology. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 35540–7 |year= 2001 |pmid= 10945981 |doi= 10.1074/jbc.M004014200
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Korotkov KV, Kumaraswamy E, Zhou Y, "et al." |title=Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 15330–6 |year= 2001 |pmid= 11278576 |doi= 10.1074/jbc.M009861200
*cite journal | author=Kumaraswamy E, Korotkov KV, Diamond AM, "et al." |title=Genetic and functional analysis of mammalian Sep15 selenoprotein. |journal=Meth. Enzymol. |volume=347 |issue= |pages= 187–97 |year= 2002 |pmid= 11898406 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wu HJ, Lin C, Zha YY, "et al." |title= [Redox reactions of Sep15 and its relationship with tumor development] |journal=Ai Zheng |volume=22 |issue= 2 |pages= 119–22 |year= 2003 |pmid= 12600282 |doi=
*cite journal | author=Gevaert K, Goethals M, Martens L, "et al." |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810
*cite journal | author=Apostolou S, Klein JO, Mitsuuchi Y, "et al." |title=Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype. |journal=Oncogene |volume=23 |issue= 29 |pages= 5032–40 |year= 2004 |pmid= 15107826 |doi= 10.1038/sj.onc.1207683
*cite journal | author=Wellenreuther R, Schupp I, Poustka A, "et al." |title=SMART amplification combined with cDNA size fractionation in order to obtain large full-length clones. |journal=BMC Genomics |volume=5 |issue= 1 |pages= 36 |year= 2004 |pmid= 15198809 |doi= 10.1186/1471-2164-5-36
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727

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