GPAA1

Glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast), also known as GPAA1, is a human gene.cite web | title = Entrez Gene: GPAA1 glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8733| accessdate = ]

PBB_Summary
section_title =
summary_text = Posttranslational glycosylphosphatidylinositol (GPI) anchor attachment serves as a general mechanism for linking proteins to the cell surface membrane. The protein encoded by this gene presumably functions in GPI anchoring at the GPI transfer step. The mRNA transcript is ubiquitously expressed in both fetal and adult tissues. The anchor attachment protein 1 contains an N-terminal signal sequence, 1 cAMP- and cGMP-dependent protein kinase phosphorylation site, 1 leucine zipper pattern, 2 potential N-glycosylation sites, and 8 putative transmembrane domains.cite web | title = Entrez Gene: GPAA1 glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8733| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hiroi Y, Komuro I, Chen R, "et al." |title=Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins. |journal=FEBS Lett. |volume=421 |issue= 3 |pages= 252–8 |year= 1998 |pmid= 9468317 |doi=
*cite journal | author=Hiroi Y, Komuro I, Matsushita I, "et al." |title=Assignment of the human GPAA1 gene, which encodes a product required for the attachment of glycosylphosphatidylinositols to proteins, at 8q24. |journal=Genomics |volume=54 |issue= 2 |pages= 354–5 |year= 1999 |pmid= 9828142 |doi= 10.1006/geno.1998.5490
*cite journal | author=Inoue N, Ohishi K, Endo Y, "et al." |title=Human and mouse GPAA1 (Glycosylphosphatidylinositol anchor attachment 1) genes: genomic structures, chromosome loci and the presence of a minor class intron. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 3-4 |pages= 199–205 |year= 1999 |pmid= 10393431 |doi=
*cite journal | author=Ohishi K, Inoue N, Maeda Y, "et al." |title=Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins. |journal=Mol. Biol. Cell |volume=11 |issue= 5 |pages= 1523–33 |year= 2000 |pmid= 10793132 |doi=
*cite journal | author=Ohishi K, Inoue N, Kinoshita T |title=PIG-S and PIG-T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8. |journal=EMBO J. |volume=20 |issue= 15 |pages= 4088–98 |year= 2001 |pmid= 11483512 |doi= 10.1093/emboj/20.15.4088
*cite journal | author=Vainauskas S, Maeda Y, Kurniawan H, "et al." |title=Structural requirements for the recruitment of Gaa1 into a functional glycosylphosphatidylinositol transamidase complex. |journal=J. Biol. Chem. |volume=277 |issue= 34 |pages= 30535–42 |year= 2002 |pmid= 12052837 |doi= 10.1074/jbc.M205402200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ohishi K, Nagamune K, Maeda Y, Kinoshita T |title=Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge. |journal=J. Biol. Chem. |volume=278 |issue= 16 |pages= 13959–67 |year= 2003 |pmid= 12582175 |doi= 10.1074/jbc.M300586200
*cite journal | author=Hong Y, Ohishi K, Kang JY, "et al." |title=Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. |journal=Mol. Biol. Cell |volume=14 |issue= 5 |pages= 1780–9 |year= 2004 |pmid= 12802054 |doi= 10.1091/mbc.E02-12-0794
*cite journal | author=Vainauskas S, Menon AK |title=A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase. |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 6540–5 |year= 2004 |pmid= 14660601 |doi= 10.1074/jbc.M312191200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Vainauskas S, Menon AK |title=Endoplasmic reticulum localization of Gaa1 and PIG-T, subunits of the glycosylphosphatidylinositol transamidase complex. |journal=J. Biol. Chem. |volume=280 |issue= 16 |pages= 16402–9 |year= 2005 |pmid= 15713669 |doi= 10.1074/jbc.M414253200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Ho JC, Cheung ST, Patil M, "et al." |title=Increased expression of glycosyl-phosphatidylinositol anchor attachment protein 1 (GPAA1) is associated with gene amplification in hepatocellular carcinoma. |journal=Int. J. Cancer |volume=119 |issue= 6 |pages= 1330–7 |year= 2006 |pmid= 16642471 |doi= 10.1002/ijc.22005

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