ST8SIA2

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2, also known as ST8SIA2, is a human gene.cite web | title = Entrez Gene: ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8128| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29.cite web | title = Entrez Gene: ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8128| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Scheidegger EP, Sternberg LR, Roth J, Lowe JB |title=A human STX cDNA confers polysialic acid expression in mammalian cells. |journal=J. Biol. Chem. |volume=270 |issue= 39 |pages= 22685–8 |year= 1995 |pmid= 7559389 |doi=
*cite journal | author=Munro S |title=An investigation of the role of transmembrane domains in Golgi protein retention. |journal=EMBO J. |volume=14 |issue= 19 |pages= 4695–704 |year= 1995 |pmid= 7588599 |doi=
*cite journal | author=Kitagawa H, Paulson JC |title=Differential expression of five sialyltransferase genes in human tissues. |journal=J. Biol. Chem. |volume=269 |issue= 27 |pages= 17872–8 |year= 1994 |pmid= 8027041 |doi=
*cite journal | author=Kojima N, Tachida Y, Yoshida Y, Tsuji S |title=Characterization of mouse ST8Sia II (STX) as a neural cell adhesion molecule-specific polysialic acid synthase. Requirement of core alpha1,6-linked fucose and a polypeptide chain for polysialylation. |journal=J. Biol. Chem. |volume=271 |issue= 32 |pages= 19457–63 |year= 1996 |pmid= 8702635 |doi=
*cite journal | author=Angata K, Nakayama J, Fredette B, "et al." |title=Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule. Tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST. |journal=J. Biol. Chem. |volume=272 |issue= 11 |pages= 7182–90 |year= 1997 |pmid= 9054414 |doi=
*cite journal | author=Close BE, Colley KJ |title=In vivo autopolysialylation and localization of the polysialyltransferases PST and STX. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34586–93 |year= 1999 |pmid= 9852130 |doi=
*cite journal | author=Angata K, Suzuki M, McAuliffe J, "et al." |title=Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18594–601 |year= 2000 |pmid= 10766765 |doi= 10.1074/jbc.M910204199
*cite journal | author=Close BE, Wilkinson JM, Bohrer TJ, "et al." |title=The polysialyltransferase ST8Sia II/STX: posttranslational processing and role of autopolysialylation in the polysialylation of neural cell adhesion molecule. |journal=Glycobiology |volume=11 |issue= 11 |pages= 997–1008 |year= 2002 |pmid= 11744634 |doi=
*cite journal | author=Angata K, Suzuki M, Fukuda M |title=ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36808–17 |year= 2002 |pmid= 12138100 |doi= 10.1074/jbc.M204632200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Lazzell DR, Belizaire R, Thakur P, "et al." |title=SV2B regulates synaptotagmin 1 by direct interaction. |journal=J. Biol. Chem. |volume=279 |issue= 50 |pages= 52124–31 |year= 2005 |pmid= 15466855 |doi= 10.1074/jbc.M407502200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Beecken WD, Engl T, Ogbomo H, "et al." |title=Valproic acid modulates NCAM polysialylation and polysialyltransferase mRNA expression in human tumor cells. |journal=Int. Immunopharmacol. |volume=5 |issue= 4 |pages= 757–69 |year= 2005 |pmid= 15710344 |doi= 10.1016/j.intimp.2004.12.009
*cite journal | author=Arai M, Yamada K, Toyota T, "et al." |title=Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia. |journal=Biol. Psychiatry |volume=59 |issue= 7 |pages= 652–9 |year= 2006 |pmid= 16229822 |doi= 10.1016/j.biopsych.2005.08.016

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