- SAC (gene)
Testicular soluble adenylyl cyclase, also known as SAC, is a human
gene .cite web | title = Entrez Gene: SAC testicular soluble adenylyl cyclase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55811| accessdate = ]PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble in testis but particulate in sperm and other tissues. It is unlike other mammalian adenylyl cyclases because it is insensitive to G protein or forskolin regulation and is directly regulated by bicarbonate. It is localized in the cytoplasm and to organelles and is thought to function as a general bicarbonate sensor throughout the body. It plays an important role in the generation of cAMP in spermatozoa, playing possible roles in sperm capacitation, hypermotility, and/or the acrosome reaction.cite web | title = Entrez Gene: SAC testicular soluble adenylyl cyclase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55811| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Wuttke MS, Buck J, Levin LR |title=Bicarbonate-regulated soluble adenylyl cyclase. |journal=JOP |volume=2 |issue= 4 Suppl |pages= 154–8 |year= 2002 |pmid= 11875252 |doi=
*cite journal | author=Hukovic N, Panetta R, Kumar U, "et al." |title=The cytoplasmic tail of the human somatostatin receptor type 5 is crucial for interaction with adenylyl cyclase and in mediating desensitization and internalization. |journal=J. Biol. Chem. |volume=273 |issue= 33 |pages= 21416–22 |year= 1998 |pmid= 9694905 |doi=
*cite journal | author=Buck J, Sinclair ML, Schapal L, "et al." |title=Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 1 |pages= 79–84 |year= 1999 |pmid= 9874775 |doi=
*cite journal | author=Hayes JS, Lawler OA, Walsh MT, Kinsella BT |title=The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling. |journal=J. Biol. Chem. |volume=274 |issue= 34 |pages= 23707–18 |year= 1999 |pmid= 10446129 |doi=
*cite journal | author=Sinclair ML, Wang XY, Mattia M, "et al." |title=Specific expression of soluble adenylyl cyclase in male germ cells. |journal=Mol. Reprod. Dev. |volume=56 |issue= 1 |pages= 6–11 |year= 2000 |pmid= 10737962 |doi= 10.1002/(SICI)1098-2795(200005)56:1<6::AID-MRD2>3.0.CO;2-M |doilabel=10.1002/(SICI)1098-2795(200005)56:16::AID-MRD23.0.CO;2-M
*cite journal | author=Chen Y, Cann MJ, Litvin TN, "et al." |title=Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. |journal=Science |volume=289 |issue= 5479 |pages= 625–8 |year= 2000 |pmid= 10915626 |doi=
*cite journal | author=Jaiswal BS, Conti M |title=Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 31698–708 |year= 2001 |pmid= 11423534 |doi= 10.1074/jbc.M011698200
*cite journal | author=Reed BY, Gitomer WL, Heller HJ, "et al." |title=Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 4 |pages= 1476–85 |year= 2002 |pmid= 11932268 |doi=
*cite journal | author=Zippin JH, Chen Y, Nahirney P, "et al." |title=Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. |journal=FASEB J. |volume=17 |issue= 1 |pages= 82–4 |year= 2003 |pmid= 12475901 |doi= 10.1096/fj.02-0598fje
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Litvin TN, Kamenetsky M, Zarifyan A, "et al." |title=Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate. |journal=J. Biol. Chem. |volume=278 |issue= 18 |pages= 15922–6 |year= 2003 |pmid= 12609998 |doi= 10.1074/jbc.M212475200
*cite journal | author=Jaiswal BS, Conti M |title=Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 19 |pages= 10676–81 |year= 2003 |pmid= 12958208 |doi= 10.1073/pnas.1831008100
*cite journal | author=Marjanovic JA, Li Z, Stojanovic A, Du X |title=Stimulatory roles of nitric-oxide synthase 3 and guanylyl cyclase in platelet activation. |journal=J. Biol. Chem. |volume=280 |issue= 45 |pages= 37430–8 |year= 2006 |pmid= 16144836 |doi= 10.1074/jbc.M506518200
*cite journal | author=Schmid A, Sutto Z, Nlend MC, "et al." |title=Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. |journal=J. Gen. Physiol. |volume=130 |issue= 1 |pages= 99–109 |year= 2007 |pmid= 17591988 |doi= 10.1085/jgp.200709784PBB_Controls
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