[cite web | title = Entrez Gene: GOLPH2 golgi phosphoprotein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51280| accessdate = ] ] PBB_Summary
section_title =
summary_text = The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a type II Golgi transmembrane protein. It processes protein synthesized in the rough endoplasmic reticulum and assists in the transport of protein cargo through the Golgi apparatus. The expression of this encoded protein has been observed to be upregulated in response to viral infection. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.[cite web | title = Entrez Gene: GOLPH2 golgi phosphoprotein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51280| accessdate = ] ]
It is overexpressed in prostate cancer.[cite journal |author=Laxman B, Morris DS, Yu J, "et al" |title=A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer |journal=Cancer Res. |volume=68 |issue=3 |pages=645–9 |year=2008 |month=February |pmid=18245462 |doi=10.1158/0008-5472.CAN-07-3224 |url=http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=18245462] ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Kladney RD, Bulla GA, Guo L, "et al." |title=GP73, a novel Golgi-localized protein upregulated by viral infection. |journal=Gene |volume=249 |issue= 1-2 |pages= 53–65 |year= 2000 |pmid= 10831838 |doi=
*cite journal | author=Kladney RD, Cui X, Bulla GA, "et al." |title=Expression of GP73, a resident Golgi membrane protein, in viral and nonviral liver disease. |journal=Hepatology |volume=35 |issue= 6 |pages= 1431–40 |year= 2002 |pmid= 12029628 |doi= 10.1053/jhep.2002.32525
*cite journal | author=Bauer K, Zemlin M, Hummel M, "et al." |title=Diversification of Ig heavy chain genes in human preterm neonates prematurely exposed to environmental antigens. |journal=J. Immunol. |volume=169 |issue= 3 |pages= 1349–56 |year= 2002 |pmid= 12133958 |doi=
*cite journal | author=Puri S, Bachert C, Fimmel CJ, Linstedt AD |title=Cycling of early Golgi proteins via the cell surface and endosomes upon lumenal pH disruption. |journal=Traffic |volume=3 |issue= 9 |pages= 641–53 |year= 2003 |pmid= 12191016 |doi=
*cite journal | author=Kladney RD, Tollefson AE, Wold WS, Fimmel CJ |title=Upregulation of the Golgi protein GP73 by adenovirus infection requires the E1A CtBP interaction domain. |journal=Virology |volume=301 |issue= 2 |pages= 236–46 |year= 2002 |pmid= 12359426 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zhang H, Li XJ, Martin DB, Aebersold R |title=Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. |journal=Nat. Biotechnol. |volume=21 |issue= 6 |pages= 660–6 |year= 2003 |pmid= 12754519 |doi= 10.1038/nbt827
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Stelzl U, Worm U, Lalowski M, "et al." |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029
*cite journal | author=Otsuki T, Ota T, Nishikawa T, "et al." |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065
*cite journal | author=Ramachandran P, Boontheung P, Xie Y, "et al." |title=Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. |journal=J. Proteome Res. |volume=5 |issue= 6 |pages= 1493–503 |year= 2006 |pmid= 16740002 |doi= 10.1021/pr050492k
*cite journal | author=Bachert C, Fimmel C, Linstedt AD |title=Endosomal trafficking and proprotein convertase cleavage of cis Golgi protein GP73 produces marker for hepatocellular carcinoma. |journal=Traffic |volume=8 |issue= 10 |pages= 1415–23 |year= 2007 |pmid= 17662025 |doi= 10.1111/j.1600-0854.2007.00621.x
PBB_Controls
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update_summary = yes
update_citations = yes
