SP110

SP110 nuclear body protein, also known as SP110, is a human gene.cite web | title = Entrez Gene: SP110 SP110 nuclear body protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3431| accessdate = ]

PBB_Summary
section_title =
summary_text = The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified.cite web | title = Entrez Gene: SP110 SP110 nuclear body protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3431| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kadereit S, Gewert DR, Galabru J, "et al." |title=Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins. |journal=J. Biol. Chem. |volume=268 |issue= 32 |pages= 24432–41 |year= 1993 |pmid= 7693701 |doi=
*cite journal | author=Welsh GI, Kadereit S, Coccia EM, "et al." |title=Colocalization within the nucleolus of two highly related IFN-induced human nuclear phosphoproteins with nucleolin. |journal=Exp. Cell Res. |volume=250 |issue= 1 |pages= 62–74 |year= 1999 |pmid= 10388521 |doi= 10.1006/excr.1999.4505
*cite journal | author=Bloch DB, Nakajima A, Gulick T, "et al." |title=Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator. |journal=Mol. Cell. Biol. |volume=20 |issue= 16 |pages= 6138–46 |year= 2000 |pmid= 10913195 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Izmailova E, Bertley FM, Huang Q, "et al." |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822
*cite journal | author=Watashi K, Hijikata M, Tagawa A, "et al." |title=Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7498–509 |year= 2003 |pmid= 14559998 |doi=
*cite journal | author=Nicewonger J, Suck G, Bloch D, Swaminathan S |title=Epstein-Barr virus (EBV) SM protein induces and recruits cellular Sp110b to stabilize mRNAs and enhance EBV lytic gene expression. |journal=J. Virol. |volume=78 |issue= 17 |pages= 9412–22 |year= 2004 |pmid= 15308735 |doi= 10.1128/JVI.78.17.9412-9422.2004
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Roscioli T, Cliffe ST, Bloch DB, "et al." |title=Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease. |journal=Nat. Genet. |volume=38 |issue= 6 |pages= 620–2 |year= 2006 |pmid= 16648851 |doi= 10.1038/ng1780
*cite journal | author=Tosh K, Campbell SJ, Fielding K, "et al." |title=Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 27 |pages= 10364–8 |year= 2006 |pmid= 16803959 |doi= 10.1073/pnas.0603340103
*cite journal | author=Thye T, Browne EN, Chinbuah MA, "et al." |title=No associations of human pulmonary tuberculosis with Sp110 variants. |journal=J. Med. Genet. |volume=43 |issue= 7 |pages= e32 |year= 2006 |pmid= 16816019 |doi= 10.1136/jmg.2005.037960
*cite journal | author=Warren EH, Vigneron NJ, Gavin MA, "et al." |title=An antigen produced by splicing of noncontiguous peptides in the reverse order. |journal=Science |volume=313 |issue= 5792 |pages= 1444–7 |year= 2006 |pmid= 16960008 |doi= 10.1126/science.1130660
*cite journal | author=Szeszko JS, Healy B, Stevens H, "et al." |title=Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis. |journal=Hum. Genet. |volume=121 |issue= 2 |pages= 155–60 |year= 2007 |pmid= 17149599 |doi= 10.1007/s00439-006-0293-z
*cite journal | author=Babb C, Keet EH, van Helden PD, Hoal EG |title=SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population. |journal=Hum. Genet. |volume=121 |issue= 3-4 |pages= 521–2 |year= 2007 |pmid= 17287948 |doi= 10.1007/s00439-007-0335-1
*cite journal | author=Cliffe ST, Wong M, Taylor PJ, "et al." |title=The first prenatal diagnosis for veno-occlusive disease and immunodeficiency syndrome, an autosomal recessive condition associated with mutations in SP110. |journal=Prenat. Diagn. |volume=27 |issue= 7 |pages= 674–6 |year= 2007 |pmid= 17510920 |doi= 10.1002/pd.1759
*cite journal | author=de la Fuente J, Manzano-Roman R, Blouin EF, "et al." |title=Sp110 transcription is induced and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. |journal=BMC Infect. Dis. |volume=7 |issue= |pages= 110 |year= 2007 |pmid= 17883869 |doi= 10.1186/1471-2334-7-110

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