HPN (gene)

HPN (gene)

Hepsin (transmembrane protease, serine 1), also known as HPN, is a human gene.cite web | title = Entrez Gene: HPN hepsin (transmembrane protease, serine 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3249| accessdate = ]

PBB_Summary
section_title =
summary_text = Hepsin is a cell surface serine protease. [supplied by OMIM] cite web | title = Entrez Gene: HPN hepsin (transmembrane protease, serine 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3249| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wu Q |title=Gene targeting in hemostasis. Hepsin. |journal=Front. Biosci. |volume=6 |issue= |pages= D192–200 |year= 2001 |pmid= 11171558 |doi=
*cite journal | author=Tsuji A, Torres-Rosado A, Arai T, "et al." |title=Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization. |journal=J. Biol. Chem. |volume=266 |issue= 25 |pages= 16948–53 |year= 1991 |pmid= 1885621 |doi=
*cite journal | author=Leytus SP, Loeb KR, Hagen FS, "et al." |title=A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells. |journal=Biochemistry |volume=27 |issue= 3 |pages= 1067–74 |year= 1988 |pmid= 2835076 |doi=
*cite journal | author=Kazama Y, Hamamoto T, Foster DC, Kisiel W |title=Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation. |journal=J. Biol. Chem. |volume=270 |issue= 1 |pages= 66–72 |year= 1995 |pmid= 7814421 |doi=
*cite journal | author=Torres-Rosado A, O'Shea KS, Tsuji A, "et al." |title=Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 15 |pages= 7181–5 |year= 1993 |pmid= 8346233 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chen Z, Fan Z, McNeal JE, "et al." |title=Hepsin and maspin are inversely expressed in laser capture microdissectioned prostate cancer. |journal=J. Urol. |volume=169 |issue= 4 |pages= 1316–9 |year= 2003 |pmid= 12629351 |doi= 10.1097/01.ju.0000050648.40164.0d
*cite journal | author=Somoza JR, Ho JD, Luong C, "et al." |title=The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain. |journal=Structure |volume=11 |issue= 9 |pages= 1123–31 |year= 2004 |pmid= 12962630 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kirchhofer D, Peek M, Lipari MT, "et al." |title=Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI-1B) and HAI-2. |journal=FEBS Lett. |volume=579 |issue= 9 |pages= 1945–50 |year= 2005 |pmid= 15792801 |doi= 10.1016/j.febslet.2005.01.085
*cite journal | author=Pal P, Xi H, Kaushal R, "et al." |title=Variants in the HEPSIN gene are associated with prostate cancer in men of European origin. |journal=Hum. Genet. |volume=120 |issue= 2 |pages= 187–92 |year= 2007 |pmid= 16783571 |doi= 10.1007/s00439-006-0204-3
*cite journal | author=Moran P, Li W, Fan B, "et al." |title=Pro-urokinase-type plasminogen activator is a substrate for hepsin. |journal=J. Biol. Chem. |volume=281 |issue= 41 |pages= 30439–46 |year= 2006 |pmid= 16908524 |doi= 10.1074/jbc.M605440200
*cite journal | author=Betsunoh H, Mukai S, Akiyama Y, "et al." |title=Clinical relevance of hepsin and hepatocyte growth factor activator inhibitor type 2 expression in renal cell carcinoma. |journal=Cancer Sci. |volume=98 |issue= 4 |pages= 491–8 |year= 2007 |pmid= 17309599 |doi= 10.1111/j.1349-7006.2007.00412.x

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