FBXW11

F-box and WD repeat domain containing 11, also known as FBXW11, is a human gene.cite web | title = Entrez Gene: FBXW11 F-box and WD repeat domain containing 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23291| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class and, in addition to an F-box, contains multiple WD40 repeats. This gene contains at least 14 exons, and its alternative splicing generates 3 transcript variants diverging at the presence/absence of two alternate exons.cite web | title = Entrez Gene: FBXW11 F-box and WD repeat domain containing 11| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23291| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ishikawa K, Nagase T, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi=
*cite journal | author=Cenciarelli C, Chiaur DS, Guardavaccaro D, "et al." |title=Identification of a family of human F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1177–9 |year= 1999 |pmid= 10531035 |doi= 10.1016/S0960-9822(00)80020-2
*cite journal | author=Suzuki H, Chiba T, Suzuki T, "et al." |title=Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination. |journal=J. Biol. Chem. |volume=275 |issue= 4 |pages= 2877–84 |year= 2000 |pmid= 10644755 |doi=
*cite journal | author=Koike J, Sagara N, Kirikoshi H, "et al." |title=Molecular cloning and genomic structure of the betaTRCP2 gene on chromosome 5q35.1. |journal=Biochem. Biophys. Res. Commun. |volume=269 |issue= 1 |pages= 103–9 |year= 2000 |pmid= 10694485 |doi= 10.1006/bbrc.2000.2241
*cite journal | author=Bhatia N, Herter JR, Slaga TJ, "et al." |title=Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB. |journal=Oncogene |volume=21 |issue= 10 |pages= 1501–9 |year= 2002 |pmid= 11896578 |doi= 10.1038/sj.onc.1205311
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Dias DC, Dolios G, Wang R, Pan ZQ |title=CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16601–6 |year= 2003 |pmid= 12481031 |doi= 10.1073/pnas.252646399
*cite journal | author=Busino L, Donzelli M, Chiesa M, "et al." |title=Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. |journal=Nature |volume=426 |issue= 6962 |pages= 87–91 |year= 2003 |pmid= 14603323 |doi= 10.1038/nature02082
*cite journal | author=Bouwmeester T, Bauch A, Ruffner H, "et al." |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086
*cite journal | author=Watanabe N, Arai H, Nishihara Y, "et al." |title=M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 13 |pages= 4419–24 |year= 2004 |pmid= 15070733 |doi= 10.1073/pnas.0307700101
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Koolen DA, Herbergs J, Veltman JA, "et al." |title=Holoprosencephaly and preaxial polydactyly associated with a 1.24 Mb duplication encompassing FBXW11 at 5q35.1. |journal=J. Hum. Genet. |volume=51 |issue= 8 |pages= 721–6 |year= 2006 |pmid= 16865294 |doi= 10.1007/s10038-006-0010-8
*cite journal | author=Butticaz C, Michielin O, Wyniger J, "et al." |title=Silencing of both beta-TrCP1 and HOS (beta-TrCP2) is required to suppress human immunodeficiency virus type 1 Vpu-mediated CD4 down-modulation. |journal=J. Virol. |volume=81 |issue= 3 |pages= 1502–5 |year= 2007 |pmid= 17121803 |doi= 10.1128/JVI.01711-06
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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