GCHFR

GTP cyclohydrolase I feedback regulator, also known as GCHFR, is a human gene.cite web | title = Entrez Gene: GCHFR GTP cyclohydrolase I feedback regulator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2644| accessdate = ]

PBB_Summary
section_title =
summary_text = GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.cite web | title = Entrez Gene: GCHFR GTP cyclohydrolase I feedback regulator| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2644| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hochstrasser DF, Frutiger S, Paquet N, "et al." |title=Human liver protein
journal=Electrophoresis |volume=13 |issue= 12 |pages= 992–1001 |year= 1993 |pmid= 1286669 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Milstien S, Jaffe H, Kowlessur D, Bonner TI |title=Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP. |journal=J. Biol. Chem. |volume=271 |issue= 33 |pages= 19743–51 |year= 1996 |pmid= 8702680 |doi=
*cite journal | author=Yoneyama T, Brewer JM, Hatakeyama K |title=GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expression. |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 9690–6 |year= 1997 |pmid= 9092499 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Bader G, Schiffmann S, Herrmann A, "et al." |title=Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP. |journal=J. Mol. Biol. |volume=312 |issue= 5 |pages= 1051–7 |year= 2001 |pmid= 11580249 |doi= 10.1006/jmbi.2001.5011
*cite journal | author=Werner ER, Bahrami S, Heller R, Werner-Felmayer G |title=Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10129–33 |year= 2002 |pmid= 11799107 |doi= 10.1074/jbc.M107326200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gesierich A, Niroomand F, Tiefenbacher CP |title=Role of human GTP cyclohydrolase I and its regulatory protein in tetrahydrobiopterin metabolism. |journal=Basic Res. Cardiol. |volume=98 |issue= 2 |pages= 69–75 |year= 2003 |pmid= 12607127 |doi= 10.1007/s00395-003-0394-y
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kalivendi S, Hatakeyama K, Whitsett J, "et al." |title=Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide--a role for GFRP? |journal=Free Radic. Biol. Med. |volume=38 |issue= 4 |pages= 481–91 |year= 2006 |pmid= 15649650 |doi= 10.1016/j.freeradbiomed.2004.11.004
*cite journal | author=Chavan B, Gillbro JM, Rokos H, Schallreuter KU |title=GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes. |journal=J. Invest. Dermatol. |volume=126 |issue= 11 |pages= 2481–9 |year= 2007 |pmid= 16778797 |doi= 10.1038/sj.jid.5700425
*cite journal | author=Ohta E, Funayama M, Ichinose H, "et al." |title=Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia. |journal=Arch. Neurol. |volume=63 |issue= 11 |pages= 1605–10 |year= 2006 |pmid= 17101830 |doi= 10.1001/archneur.63.11.1605
*cite journal | author=Kontostavlaki DP, Panayotacopoulou MT, Sluijs JA, "et al." |title=Co-expression of tyrosine hydroxylase and GTP cyclohydrolase I in arginine vasopressin-synthesizing neurons of the human supraoptic nucleus demonstrated by laser microdissection and real-time PCR. |journal=Neuroendocrinology |volume=84 |issue= 6 |pages= 386–95 |year= 2007 |pmid= 17135716 |doi= 10.1159/000097487

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