RAB3GAP1

RAB3 GTPase activating protein subunit 1 (catalytic), also known as RAB3GAP1, is a human gene.cite web | title = Entrez Gene: RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22930| accessdate = ]

PBB_Summary
section_title =
summary_text = Members of the RAB3 protein family (see RAB3A; MIM 179490) are implicated in regulated exocytosis of neurotransmitters and hormones. RAB3GAP, which is involved in regulation of RAB3 activity, is a heterodimeric complex consisting a 130-kD catalytic subunit and a 150-kD noncatalytic subunit (MIM 609275). RAB3GAP specifically converts active RAB3-GTP to the inactive form RAB3-GDP (Aligianis et al., 2005). [supplied by OMIM] cite web | title = Entrez Gene: RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22930| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nomura N, Nagase T, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–9 |year= 1995 |pmid= 7584044 |doi=
*cite journal | author=Warburg M, Sjö O, Fledelius HC, Pedersen SA |title=Autosomal recessive microcephaly, microcornea, congenital cataract, mental retardation, optic atrophy, and hypogenitalism. Micro syndrome. |journal=Am. J. Dis. Child. |volume=147 |issue= 12 |pages= 1309–12 |year= 1994 |pmid= 8249951 |doi=
*cite journal | author=Fukui K, Sasaki T, Imazumi K, "et al." |title=Isolation and characterization of a GTPase activating protein specific for the Rab3 subfamily of small G proteins. |journal=J. Biol. Chem. |volume=272 |issue= 8 |pages= 4655–8 |year= 1997 |pmid= 9030515 |doi=
*cite journal | author=Nagano F, Sasaki T, Fukui K, "et al." |title=Molecular cloning and characterization of the noncatalytic subunit of the Rab3 subfamily-specific GTPase-activating protein. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24781–5 |year= 1998 |pmid= 9733780 |doi=
*cite journal | author=Oishi H, Sasaki T, Nagano F, "et al." |title=Localization of the Rab3 small G protein regulators in nerve terminals and their involvement in Ca2+-dependent exocytosis. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34580–5 |year= 1999 |pmid= 9852129 |doi=
*cite journal | author=Rodríguez Criado G, Rufo M, Gómez de Terreros I |title=A second family with Micro syndrome. |journal=Clin. Dysmorphol. |volume=8 |issue= 4 |pages= 241–5 |year= 1999 |pmid= 10532171 |doi=
*cite journal | author=Clabecq A, Henry JP, Darchen F |title=Biochemical characterization of Rab3-GTPase-activating protein reveals a mechanism similar to that of Ras-GAP. |journal=J. Biol. Chem. |volume=275 |issue= 41 |pages= 31786–91 |year= 2000 |pmid= 10859313 |doi= 10.1074/jbc.M003705200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kawabe H, Sakisaka T, Yasumi M, "et al." |title=A novel rabconnectin-3-binding protein that directly binds a GDP/GTP exchange protein for Rab3A small G protein implicated in Ca(2+)-dependent exocytosis of neurotransmitter. |journal=Genes Cells |volume=8 |issue= 6 |pages= 537–46 |year= 2004 |pmid= 12786944 |doi=
*cite journal | author=Cheviet S, Coppola T, Haynes LP, "et al." |title=The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis. |journal=Mol. Endocrinol. |volume=18 |issue= 1 |pages= 117–26 |year= 2004 |pmid= 14593078 |doi= 10.1210/me.2003-0300
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Aligianis IA, Johnson CA, Gissen P, "et al." |title=Mutations of the catalytic subunit of RAB3GAP cause Warburg Micro syndrome. |journal=Nat. Genet. |volume=37 |issue= 3 |pages= 221–3 |year= 2005 |pmid= 15696165 |doi= 10.1038/ng1517
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Tsuritani K, Irie T, Yamashita R, "et al." |title=Distinct class of putative "non-conserved" promoters in humans: comparative studies of alternative promoters of human and mouse genes. |journal=Genome Res. |volume=17 |issue= 7 |pages= 1005–14 |year= 2007 |pmid= 17567985 |doi= 10.1101/gr.6030107

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