CHRNA5

Cholinergic receptor, nicotinic, alpha 5, also known as CHRNA5, is a human gene.cite web | title = Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1138| accessdate = ]

PBB_Summary
section_title =
summary_text = Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits. See MIM 118508 for additional background information on AChRs. [supplied by OMIM] cite web | title = Entrez Gene: CHRNA5 cholinergic receptor, nicotinic, alpha 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1138| accessdate = ]

ee also

* Nicotinic acetylcholine receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hogg RC, Raggenbass M, Bertrand D |title=Nicotinic acetylcholine receptors: from structure to brain function. |journal=Rev. Physiol. Biochem. Pharmacol. |volume=147 |issue= |pages= 1–46 |year= 2003 |pmid= 12783266 |doi= 10.1007/s10254-003-0005-1
*cite journal | author=Anand R, Lindstrom J |title=Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans. |journal=Genomics |volume=13 |issue= 4 |pages= 962–7 |year= 1992 |pmid= 1505988 |doi=
*cite journal | author=Chini B, Clementi F, Hukovic N, Sher E |title=Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 5 |pages= 1572–6 |year= 1992 |pmid= 1542648 |doi=
*cite journal | author=Raimondi E, Rubboli F, Moralli D, "et al." |title=Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits. |journal=Genomics |volume=12 |issue= 4 |pages= 849–50 |year= 1992 |pmid= 1572664 |doi=
*cite journal | author=Eng CM, Kozak CA, Beaudet AL, Zoghbi HY |title=Mapping of multiple subunits of the neuronal nicotinic acetylcholine receptor to chromosome 15 in man and chromosome 9 in mouse. |journal=Genomics |volume=9 |issue= 2 |pages= 278–82 |year= 1991 |pmid= 2004777 |doi=
*cite journal | author=Elliott KJ, Ellis SB, Berckhan KJ, "et al." |title=Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits. |journal=J. Mol. Neurosci. |volume=7 |issue= 3 |pages= 217–28 |year= 1997 |pmid= 8906617 |doi=
*cite journal | author=Groot Kormelink PJ, Luyten WH |title=Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32. |journal=FEBS Lett. |volume=400 |issue= 3 |pages= 309–14 |year= 1997 |pmid= 9009220 |doi=
*cite journal | author=Navaneetham D, Penn A, Howard J, Conti-Fine BM |title=Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses. |journal=Cell. Mol. Biol. (Noisy-le-grand) |volume=43 |issue= 3 |pages= 433–42 |year= 1997 |pmid= 9193799 |doi=
*cite journal | author=Gerzanich V, Wang F, Kuryatov A, Lindstrom J |title=alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors. |journal=J. Pharmacol. Exp. Ther. |volume=286 |issue= 1 |pages= 311–20 |year= 1998 |pmid= 9655874 |doi=
*cite journal | author=Lentz TL |title=Nicotine binding to native and substituted peptides comprising residues 188-207 of nicotinic acetylcholine receptor alpha1, alpha2, alpha3, alpha4, alpha5, and alpha7 subunits. |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 2 |pages= 480–4 |year= 2000 |pmid= 10679230 |doi= 10.1006/bbrc.2000.2155
*cite journal | author=Groot-Kormelink PJ, Boorman JP, Sivilotti LG |title=Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach. |journal=Br. J. Pharmacol. |volume=134 |issue= 4 |pages= 789–96 |year= 2001 |pmid= 11606319 |doi= 10.1038/sj.bjp.0704313
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Soldà G, Boi S, Duga S, "et al." |title=In vivo RNA-RNA duplexes from human alpha3 and alpha5 nicotinic receptor subunit mRNAs. |journal=Gene |volume=345 |issue= 2 |pages= 155–64 |year= 2005 |pmid= 15716100 |doi= 10.1016/j.gene.2004.12.005

External links

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