FARSB

Phenylalanyl-tRNA synthetase, beta subunit, also known as FARSB, is a human gene.cite web | title = Entrez Gene: FARSB phenylalanyl-tRNA synthetase, beta subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10056| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified.cite web | title = Entrez Gene: FARSB phenylalanyl-tRNA synthetase, beta subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10056| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Archambault de Vencay J, Thomes JC, Julien R |title=Phenylalanyl-tRNA synthetase of the human placenta. Evidence for different enzymatic forms in equilibrium. |journal=FEBS Lett. |volume=89 |issue= 1 |pages= 98–102 |year= 1978 |pmid= 658405 |doi=
*cite journal | author=Nazarenko IA, Peterson ET, Zakharova OD, "et al." |title=Recognition nucleotides for human phenylalanyl-tRNA synthetase. |journal=Nucleic Acids Res. |volume=20 |issue= 3 |pages= 475–8 |year= 1992 |pmid= 1741281 |doi=
*cite journal | author=Sen S, Zhou H, Ripmaster T, "et al." |title=Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 12 |pages= 6164–9 |year= 1997 |pmid= 9177188 |doi=
*cite journal | author=Rodova M, Ankilova V, Safro MG |title=Human phenylalanyl-tRNA synthetase: cloning, characterization of the deduced amino acid sequences in terms of the structural domains and coordinately regulated expression of the alpha and beta subunits in chronic myeloid leukemia cells. |journal=Biochem. Biophys. Res. Commun. |volume=255 |issue= 3 |pages= 765–73 |year= 1999 |pmid= 10049785 |doi= 10.1006/bbrc.1999.0141
*cite journal | author=Zhou X, Richon VM, Ngo L, "et al." |title=Cloning of the cDNA encoding phenylalanyl tRNA synthetase regulatory alpha-subunit-like protein whose expression is down-regulated during differentiation. |journal=Gene |volume=233 |issue= 1-2 |pages= 13–9 |year= 1999 |pmid= 10375616 |doi=
*cite journal | author=Zhang QH, Ye M, Wu XY, "et al." |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=
*cite journal | author=Moor N, Linshiz G, Safro M |title=Cloning and expression of human phenylalanyl-tRNA synthetase in Escherichia coli: comparative study of purified recombinant enzymes. |journal=Protein Expr. Purif. |volume=24 |issue= 2 |pages= 260–7 |year= 2002 |pmid= 11858721 |doi= 10.1006/prep.2001.1560
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Moor N, Lavrik O, Favre A, Safro M |title=Prokaryotic and eukaryotic tetrameric phenylalanyl-tRNA synthetases display conservation of the binding mode of the tRNA(Phe) CCA end. |journal=Biochemistry |volume=42 |issue= 36 |pages= 10697–708 |year= 2003 |pmid= 12962494 |doi= 10.1021/bi034732q
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Yu XY, Finn J, Hill JM, "et al." |title=A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases. |journal=Bioorg. Med. Chem. Lett. |volume=14 |issue= 5 |pages= 1339–42 |year= 2004 |pmid= 14980694 |doi= 10.1016/j.bmcl.2003.11.081
*cite journal | author=Vasil'eva IA, Bogachev VS, Favre A, "et al." |title=Role of low-molecular-weight substrates in functional binding of the tRNAPhe acceptor end by phenylalanyl-tRNA synthetase. |journal=Biochemistry Mosc. |volume=69 |issue= 2 |pages= 143–53 |year= 2005 |pmid= 15000680 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Andersen JS, Lam YW, Leung AK, "et al." |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes