SECISBP2

SECIS binding protein 2, also known as SECISBP2, is a human gene.cite web | title = Entrez Gene: SECISBP2 SECIS binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79048| accessdate = ]

PBB_Summary
section_title =
summary_text = The incorporation of selenocysteine into a protein requires the concerted action of an mRNA element called a sec insertion sequence (SECIS), a selenocysteine-specific translation elongation factor and a SECIS binding protein. With these elements in place, a UGA codon can be decoded as selenocysteine. The gene described in this record encodes a nuclear protein that functions as a SECIS binding protein. Mutations in this gene have been associated with a reduction in activity of a specific thyroxine deiodinase, a selenocysteine-containing enzyme, and abnormal thyroid hormone metabolism.cite web | title = Entrez Gene: SECISBP2 SECIS binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79048| accessdate = ]

ee also

* Thyroid hormone resistance

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Copeland PR, Fletcher JE, Carlson BA, "et al." |title=A novel RNA binding protein, SBP2, is required for the translation of mammalian selenoprotein mRNAs. |journal=EMBO J. |volume=19 |issue= 2 |pages= 306–14 |year= 2000 |pmid= 10637234 |doi= 10.1093/emboj/19.2.306
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Low SC, Grundner-Culemann E, Harney JW, Berry MJ |title=SECIS-SBP2 interactions dictate selenocysteine incorporation efficiency and selenoprotein hierarchy. |journal=EMBO J. |volume=19 |issue= 24 |pages= 6882–90 |year= 2001 |pmid= 11118223 |doi= 10.1093/emboj/19.24.6882
*cite journal | author=Wiemann S, Weil B, Wellenreuther R, "et al." |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701
*cite journal | author=Lescure A, Allmang C, Yamada K, "et al." |title=cDNA cloning, expression pattern and RNA binding analysis of human selenocysteine insertion sequence (SECIS) binding protein 2. |journal=Gene |volume=291 |issue= 1-2 |pages= 279–85 |year= 2002 |pmid= 12095701 |doi=
*cite journal | author=Allmang C, Carbon P, Krol A |title=The SBP2 and 15.5 kD/Snu13p proteins share the same RNA binding domain: identification of SBP2 amino acids important to SECIS RNA binding. |journal=RNA |volume=8 |issue= 10 |pages= 1308–18 |year= 2002 |pmid= 12403468 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Dumitrescu AM, Liao XH, Abdullah MS, "et al." |title=Mutations in SECISBP2 result in abnormal thyroid hormone metabolism. |journal=Nat. Genet. |volume=37 |issue= 11 |pages= 1247–52 |year= 2006 |pmid= 16228000 |doi= 10.1038/ng1654
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Papp LV, Lu J, Striebel F, "et al." |title=The redox state of SECIS binding protein 2 controls its localization and selenocysteine incorporation function. |journal=Mol. Cell. Biol. |volume=26 |issue= 13 |pages= 4895–910 |year= 2006 |pmid= 16782878 |doi= 10.1128/MCB.02284-05

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