UPK1B

Uroplakin 1B, also known as UPK1B, is a human gene.cite web | title = Entrez Gene: UPK1B uroplakin 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7348| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene.cite web | title = Entrez Gene: UPK1B uroplakin 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7348| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143–51 |year= 2002 |pmid= 11739647 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Wu XR, Medina JJ, Sun TT |title=Selective interactions of UPIa and UPIb, two members of the transmembrane 4 superfamily, with distinct single transmembrane-domained proteins in differentiated urothelial cells. |journal=J. Biol. Chem. |volume=270 |issue= 50 |pages= 29752–9 |year= 1996 |pmid= 8530366 |doi=
*cite journal | author=Finch JL, Webb GC, Evdokiou A, Cowled PA |title=Chromosomal localization of the human urothelial "tetraspan" gene, UPK1B, to 3q13.3-q21 and detection of a TaqI polymorphism. |journal=Genomics |volume=40 |issue= 3 |pages= 501–3 |year= 1997 |pmid= 9073521 |doi= 10.1006/geno.1996.4589
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Yuasa T, Yoshiki T, Tanaka T, "et al." |title=Expression of uroplakin Ib and uroplakin III genes in tissues and peripheral blood of patients with transitional cell carcinoma. |journal=Jpn. J. Cancer Res. |volume=89 |issue= 9 |pages= 879–82 |year= 1998 |pmid= 9818021 |doi=
*cite journal | author=Lobban ED, Smith BA, Hall GD, "et al." |title=Uroplakin gene expression by normal and neoplastic human urothelium. |journal=Am. J. Pathol. |volume=153 |issue= 6 |pages= 1957–67 |year= 1998 |pmid= 9846985 |doi=
*cite journal | author=Finch JL, Miller J, Aspinall JO, Cowled PA |title=Cloning of the human uroplakin 1B cDNA and analysis of its expression in urothelial-tumor cell lines and bladder-carcinoma tissue. |journal=Int. J. Cancer |volume=80 |issue= 4 |pages= 533–8 |year= 1999 |pmid= 9935153 |doi=
*cite journal | author=Ogawa K, Johansson SL, Cohen SM |title=Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract. |journal=Am. J. Pathol. |volume=155 |issue= 4 |pages= 1047–50 |year= 1999 |pmid= 10514386 |doi=
*cite journal | author=Olsburgh J, Weeks R, Selby P, Southgate J |title=Human uroplakin lb gene structure and promoter analysis. |journal=Biochim. Biophys. Acta |volume=1576 |issue= 1-2 |pages= 163–70 |year= 2002 |pmid= 12031497 |doi=
*cite journal | author=Deng FM, Liang FX, Tu L, "et al." |title=Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly. |journal=J. Cell Biol. |volume=159 |issue= 4 |pages= 685–94 |year= 2003 |pmid= 12446744 |doi= 10.1083/jcb.200204102
*cite journal | author=Tu L, Sun TT, Kreibich G |title=Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum. |journal=Mol. Biol. Cell |volume=13 |issue= 12 |pages= 4221–30 |year= 2003 |pmid= 12475947 |doi= 10.1091/mbc.E02-04-0211
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Varga AE, Leonardos L, Jackson P, "et al." |title=Methylation of a CpG island within the uroplakin Ib promoter: a possible mechanism for loss of uroplakin Ib expression in bladder carcinoma. |journal=Neoplasia |volume=6 |issue= 2 |pages= 128–35 |year= 2004 |pmid= 15140401 |doi= 10.1593/neo.03337
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes