XYLT1

Xylosyltransferase I, also known as XYLT1, is a human gene.cite web | title = Entrez Gene: XYLT1 xylosyltransferase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64131| accessdate = ]

PBB_Summary
section_title =
summary_text = Xylosyltransferase (XT; EC 2.4.2.26) catalyzes the transfer of UDP-xylose to serine residues within XT recognition sequences of target proteins. Addition of this xylose to the core protein is required for the biosynthesis of the glycosaminoglycan chains characteristic of proteoglycans. [supplied by OMIM] cite web | title = Entrez Gene: XYLT1 xylosyltransferase I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64131| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Götting C, Sollberg S, Kuhn J, "et al." |title=Serum xylosyltransferase: a new biochemical marker of the sclerotic process in systemic sclerosis. |journal=J. Invest. Dermatol. |volume=112 |issue= 6 |pages= 919–24 |year= 1999 |pmid= 10383739 |doi= 10.1046/j.1523-1747.1999.00590.x
*cite journal | author=Kuhn J, Götting C, Schnölzer M, "et al." |title=First isolation of human UDP-D-xylose: proteoglycan core protein beta-D-xylosyltransferase secreted from cultured JAR choriocarcinoma cells. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4940–7 |year= 2001 |pmid= 11087729 |doi= 10.1074/jbc.M005111200
*cite journal | author=Götting C, Kuhn J, Zahn R, "et al." |title=Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II. |journal=J. Mol. Biol. |volume=304 |issue= 4 |pages= 517–28 |year= 2001 |pmid= 11099377 |doi= 10.1006/jmbi.2000.4261
*cite journal | author=Götting C, Kuhn J, Brinkmann T, Kleesiek K |title=Xylosyltransferase activity in seminal plasma of infertile men. |journal=Clin. Chim. Acta |volume=317 |issue= 1-2 |pages= 199–202 |year= 2002 |pmid= 11814476 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Götting C, Müller S, Schöttler M, "et al." |title=Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity. |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 42566–73 |year= 2004 |pmid= 15294915 |doi= 10.1074/jbc.M401340200
*cite journal | author=Müller S, Schöttler M, Schön S, "et al." |title=Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity. |journal=Biochem. J. |volume=386 |issue= Pt 2 |pages= 227–36 |year= 2005 |pmid= 15461586 |doi= 10.1042/BJ20041206
*cite journal | author=Götting C, Hendig D, Adam A, "et al." |title=Elevated xylosyltransferase I activities in pseudoxanthoma elasticum (PXE) patients as a marker of stimulated proteoglycan biosynthesis. |journal=J. Mol. Med. |volume=83 |issue= 12 |pages= 984–92 |year= 2006 |pmid= 16133423 |doi= 10.1007/s00109-005-0693-x
*cite journal | author=Schön S, Prante C, Müller S, "et al." |title=Impact of polymorphisms in the genes encoding xylosyltransferase I and a homologue in type 1 diabetic patients with and without nephropathy. |journal=Kidney Int. |volume=68 |issue= 4 |pages= 1483–90 |year= 2005 |pmid= 16164625 |doi= 10.1111/j.1523-1755.2005.00561.x
*cite journal | author=Müller S, Disse J, Schöttler M, "et al." |title=Human xylosyltransferase I and N-terminal truncated forms: functional characterization of the core enzyme. |journal=Biochem. J. |volume=394 |issue= Pt 1 |pages= 163–71 |year= 2006 |pmid= 16225459 |doi= 10.1042/BJ20051606
*cite journal | author=Schön S, Prante C, Bahr C, "et al." |title=Cloning and recombinant expression of active full-length xylosyltransferase I (XT-I) and characterization of subcellular localization of XT-I and XT-II. |journal=J. Biol. Chem. |volume=281 |issue= 20 |pages= 14224–31 |year= 2006 |pmid= 16569644 |doi= 10.1074/jbc.M510690200
*cite journal | author=Schön S, Schulz V, Prante C, "et al." |title=Polymorphisms in the xylosyltransferase genes cause higher serum XT-I activity in patients with pseudoxanthoma elasticum (PXE) and are involved in a severe disease course. |journal=J. Med. Genet. |volume=43 |issue= 9 |pages= 745–9 |year= 2007 |pmid= 16571645 |doi= 10.1136/jmg.2006.040972
*cite journal | author=Prante C, Bieback K, Funke C, "et al." |title=The formation of extracellular matrix during chondrogenic differentiation of mesenchymal stem cells correlates with increased levels of xylosyltransferase I. |journal=Stem Cells |volume=24 |issue= 10 |pages= 2252–61 |year= 2006 |pmid= 16778156 |doi= 10.1634/stemcells.2005-0508
*cite journal | author=Schön S, Prante C, Bahr C, "et al." |title=The xylosyltransferase I gene polymorphism c.343G>T (p.A125S) is a risk factor for diabetic nephropathy in type 1 diabetes. |journal=Diabetes Care |volume=29 |issue= 10 |pages= 2295–9 |year= 2007 |pmid= 17003309 |doi= 10.2337/dc06-0344
*cite journal | author=Cuellar K, Chuong H, Hubbell SM, Hinsdale ME |title=Biosynthesis of chondroitin and heparan sulfate in chinese hamster ovary cells depends on xylosyltransferase II. |journal=J. Biol. Chem. |volume=282 |issue= 8 |pages= 5195–200 |year= 2007 |pmid= 17189266 |doi= 10.1074/jbc.M611048200
*cite journal | author=Prante C, Milting H, Kassner A, "et al." |title=Transforming growth factor beta1-regulated xylosyltransferase I activity in human cardiac fibroblasts and its impact for myocardial remodeling. |journal=J. Biol. Chem. |volume=282 |issue= 36 |pages= 26441–9 |year= 2007 |pmid= 17635914 |doi= 10.1074/jbc.M702299200

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