PRSS8

Protease, serine, 8, also known as PRSS8, is a human gene.cite web | title = Entrez Gene: PRSS8 protease, serine, 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5652| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. The proprotein is cleaved to produce a light chain and a heavy chain which are associated by a disulfide bond. It is active on peptide linkages involving the carboxyl group of lysine or arginine.cite web | title = Entrez Gene: PRSS8 protease, serine, 8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5652| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yu JX, Chao L, Chao J |title=Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA. |journal=J. Biol. Chem. |volume=270 |issue= 22 |pages= 13483–9 |year= 1995 |pmid= 7768952 |doi=
*cite journal | author=Yu JX, Chao L, Chao J |title=Prostasin is a novel human serine proteinase from seminal fluid. Purification, tissue distribution, and localization in prostate gland. |journal=J. Biol. Chem. |volume=269 |issue= 29 |pages= 18843–8 |year= 1994 |pmid= 8034638 |doi=
*cite journal | author=Yu JX, Chao L, Ward DC, Chao J |title=Structure and chromosomal localization of the human prostasin (PRSS8) gene. |journal=Genomics |volume=32 |issue= 3 |pages= 334–40 |year= 1997 |pmid= 8838796 |doi= 10.1006/geno.1996.0127
*cite journal | author=Nelson PS, Gan L, Ferguson C, "et al." |title=Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 6 |pages= 3114–9 |year= 1999 |pmid= 10077646 |doi=
*cite journal | author=Chen LM, Skinner ML, Kauffman SW, "et al." |title=Prostasin is a glycosylphosphatidylinositol-anchored active serine protease. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21434–42 |year= 2001 |pmid= 11274175 |doi= 10.1074/jbc.M011423200
*cite journal | author=Donaldson SH, Hirsh A, Li DC, "et al." |title=Regulation of the epithelial sodium channel by serine proteases in human airways. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8338–45 |year= 2002 |pmid= 11756432 |doi= 10.1074/jbc.M105044200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wang C, Chao J, Chao L |title=Adenovirus-mediated human prostasin gene delivery is linked to increased aldosterone production and hypertension in rats. |journal=Am. J. Physiol. Regul. Integr. Comp. Physiol. |volume=284 |issue= 4 |pages= R1031–6 |year= 2003 |pmid= 12626364 |doi= 10.1152/ajpregu.00660.2002
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Tong Z, Illek B, Bhagwandin VJ, "et al." |title=Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=287 |issue= 5 |pages= L928–35 |year= 2004 |pmid= 15246975 |doi= 10.1152/ajplung.00160.2004
*cite journal | author=Shipway A, Danahay H, Williams JA, "et al." |title=Biochemical characterization of prostasin, a channel activating protease. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 2 |pages= 953–63 |year= 2004 |pmid= 15474520 |doi= 10.1016/j.bbrc.2004.09.123
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Leyvraz C, Charles RP, Rubera I, "et al." |title=The epidermal barrier function is dependent on the serine protease CAP1/Prss8. |journal=J. Cell Biol. |volume=170 |issue= 3 |pages= 487–96 |year= 2005 |pmid= 16061697 |doi= 10.1083/jcb.200501038
*cite journal | author=Fan B, Wu TD, Li W, Kirchhofer D |title=Identification of hepatocyte growth factor activator inhibitor-1B as a potential physiological inhibitor of prostasin. |journal=J. Biol. Chem. |volume=280 |issue= 41 |pages= 34513–20 |year= 2005 |pmid= 16103126 |doi= 10.1074/jbc.M502119200
*cite journal | author=Chen M, Chen LM, Chai KX |title=Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG. |journal=Prostate |volume=66 |issue= 9 |pages= 911–20 |year= 2006 |pmid= 16541421 |doi= 10.1002/pros.20325
*cite journal | author=Rohan S, Tu JJ, Kao J, "et al." |title=Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes. |journal=Clin. Cancer Res. |volume=12 |issue= 23 |pages= 6937–45 |year= 2007 |pmid= 17145811 |doi= 10.1158/1078-0432.CCR-06-1268
*cite journal | author=Chen M, Fu YY, Lin CY, "et al." |title=Prostasin induces protease-dependent and independent molecular changes in the human prostate carcinoma cell line PC-3. |journal=Biochim. Biophys. Acta |volume=1773 |issue= 7 |pages= 1133–40 |year= 2007 |pmid= 17532063 |doi= 10.1016/j.bbamcr.2007.04.013

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