KIFAP3

Kinesin-associated protein 3, also known as KIFAP3, is a human gene.cite web | title = Entrez Gene: KIFAP3 kinesin-associated protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22920| accessdate = ]

PBB_Summary
section_title =
summary_text = The small G protein GDP dissociation stimulator (smg GDS) is a regulator protein having two activities on a group of small G proteins including the Rho and Rap1 family members and Ki-Ras; one is to stimulate their GDP/GTP exchange reactions, and the other is to inhibit their interactions with membranes. The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. It is thought that this protein serves as a linker between human chromosome-associated polypeptide (HCAP) and KIF3A/B, a kinesin superfamily protein in the nucleus, and that it plays a role in the interaction of chromosomes with an ATPase motor protein.cite web | title = Entrez Gene: KIFAP3 kinesin-associated protein 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22920| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Shimizu K, Kawabe H, Minami S, "et al." |title=SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase. |journal=J. Biol. Chem. |volume=271 |issue= 43 |pages= 27013–7 |year= 1996 |pmid= 8900189 |doi=
*cite journal | author=Nagata K, Puls A, Futter C, "et al." |title=The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. |journal=EMBO J. |volume=17 |issue= 1 |pages= 149–58 |year= 1998 |pmid= 9427749 |doi= 10.1093/emboj/17.1.149
*cite journal | author=Shimizu K, Shirataki H, Honda T, "et al." |title=Complex formation of SMAP/KAP3, a KIF3A/B ATPase motor-associated protein, with a human chromosome-associated polypeptide. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6591–4 |year= 1998 |pmid= 9506951 |doi=
*cite journal | author=Jimbo T, Kawasaki Y, Koyama R, "et al." |title=Identification of a link between the tumour suppressor APC and the kinesin superfamily. |journal=Nat. Cell Biol. |volume=4 |issue= 4 |pages= 323–7 |year= 2002 |pmid= 11912492 |doi= 10.1038/ncb779
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Khanna H, Hurd TW, Lillo C, "et al." |title=RPGR-ORF15, which is mutated in retinitis pigmentosa, associates with SMC1, SMC3, and microtubule transport proteins. |journal=J. Biol. Chem. |volume=280 |issue= 39 |pages= 33580–7 |year= 2005 |pmid= 16043481 |doi= 10.1074/jbc.M505827200
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Brown CL, Maier KC, Stauber T, "et al." |title=Kinesin-2 is a motor for late endosomes and lysosomes. |journal=Traffic |volume=6 |issue= 12 |pages= 1114–24 |year= 2006 |pmid= 16262723 |doi= 10.1111/j.1600-0854.2005.00347.x
*cite journal | author=Haraguchi K, Hayashi T, Jimbo T, "et al." |title=Role of the kinesin-2 family protein, KIF3, during mitosis. |journal=J. Biol. Chem. |volume=281 |issue= 7 |pages= 4094–9 |year= 2006 |pmid= 16298999 |doi= 10.1074/jbc.M507028200
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Kuraguchi M, Wang XP, Bronson RT, "et al." |title=Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. |journal=PLoS Genet. |volume=2 |issue= 9 |pages= e146 |year= 2006 |pmid= 17002498 |doi= 10.1371/journal.pgen.0020146
*cite journal | author=Stauber T, Simpson JC, Pepperkok R, Vernos I |title=A role for kinesin-2 in COPI-dependent recycling between the ER and the Golgi complex. |journal=Curr. Biol. |volume=16 |issue= 22 |pages= 2245–51 |year= 2007 |pmid= 17113389 |doi= 10.1016/j.cub.2006.09.060

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