FCN1

Ficolin (collagen/fibrinogen domain containing) 1, also known as FCN1, is a human gene.cite web | title = Entrez Gene: FCN1 ficolin (collagen/fibrinogen domain containing) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2219| accessdate = ]

PBB_Summary
section_title =
summary_text = The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity.cite web | title = Entrez Gene: FCN1 ficolin (collagen/fibrinogen domain containing) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2219| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lu J, Le Y |title=Ficolins and the fibrinogen-like domain. |journal=Immunobiology |volume=199 |issue= 2 |pages= 190–9 |year= 1999 |pmid= 9777405 |doi=
*cite journal | author=Ichijo H, Hellman U, Wernstedt C, "et al." |title=Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains. |journal=J. Biol. Chem. |volume=268 |issue= 19 |pages= 14505–13 |year= 1993 |pmid= 7686157 |doi=
*cite journal | author=Lu J, Tay PN, Kon OL, Reid KB |title=Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9. |journal=Biochem. J. |volume=313 ( Pt 2) |issue= |pages= 473–8 |year= 1996 |pmid= 8573080 |doi=
*cite journal | author=Matsushita M, Endo Y, Taira S, "et al." |title=A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin. |journal=J. Biol. Chem. |volume=271 |issue= 5 |pages= 2448–54 |year= 1996 |pmid= 8576206 |doi=
*cite journal | author=Endo Y, Sato Y, Matsushita M, Fujita T |title=Cloning and characterization of the human lectin P35 gene and its related gene. |journal=Genomics |volume=36 |issue= 3 |pages= 515–21 |year= 1997 |pmid= 8884275 |doi= 10.1006/geno.1996.0497
*cite journal | author=Harumiya S, Takeda K, Sugiura T, "et al." |title=Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1. |journal=J. Biochem. |volume=120 |issue= 4 |pages= 745–51 |year= 1997 |pmid= 8947836 |doi=
*cite journal | author=Le Y, Tan SM, Lee SH, "et al." |title=Purification and binding properties of a human ficolin-like protein. |journal=J. Immunol. Methods |volume=204 |issue= 1 |pages= 43–9 |year= 1997 |pmid= 9202708 |doi=
*cite journal | author=Matsushita M, Endo Y, Fujita T |title=Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease. |journal=J. Immunol. |volume=164 |issue= 5 |pages= 2281–4 |year= 2000 |pmid= 10679061 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Zeng L, Dai J, Ying K, "et al." |title=Identification of a novel human angiopoietin-like gene expressed mainly in heart. |journal=J. Hum. Genet. |volume=48 |issue= 3 |pages= 159–62 |year= 2003 |pmid= 12624729 |doi= 10.1007/s100380300025
*cite journal | author=Gregory LA, Thielens NM, Matsushita M, "et al." |title=The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29391–7 |year= 2004 |pmid= 15117939 |doi= 10.1074/jbc.M402687200
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Frederiksen PD, Thiel S, Larsen CB, Jensenius JC |title=M-ficolin, an innate immune defence molecule, binds patterns of acetyl groups and activates complement. |journal=Scand. J. Immunol. |volume=62 |issue= 5 |pages= 462–73 |year= 2006 |pmid= 16305643 |doi= 10.1111/j.1365-3083.2005.01685.x
*cite journal | author=Tanio M, Kondo S, Sugio S, Kohno T |title=Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain. |journal=J. Biol. Chem. |volume=282 |issue= 6 |pages= 3889–95 |year= 2007 |pmid= 17148457 |doi= 10.1074/jbc.M608627200

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