ACSL4

Acyl-CoA synthetase long-chain family member 4, also known as ACSL4, is a human gene.cite web | title = Entrez Gene: ACSL4 acyl-CoA synthetase long-chain family member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2182| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants.cite web | title = Entrez Gene: ACSL4 acyl-CoA synthetase long-chain family member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2182| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Knights KM, Jones ME |title=Inhibition kinetics of hepatic microsomal long chain fatty acid-CoA ligase by 2-arylpropionic acid non-steroidal anti-inflammatory drugs. |journal=Biochem. Pharmacol. |volume=43 |issue= 7 |pages= 1465–71 |year= 1992 |pmid= 1567471 |doi=
*cite journal | author=Piccini M, Vitelli F, Bruttini M, "et al." |title=FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation. |journal=Genomics |volume=47 |issue= 3 |pages= 350–8 |year= 1998 |pmid= 9480748 |doi= 10.1006/geno.1997.5104
*cite journal | author=Cao Y, Traer E, Zimmerman GA, "et al." |title=Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4). |journal=Genomics |volume=49 |issue= 2 |pages= 327–30 |year= 1998 |pmid= 9598324 |doi= 10.1006/geno.1998.5268
*cite journal | author=Jonsson JJ, Renieri A, Gallagher PG, "et al." |title=Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis: a new X linked contiguous gene deletion syndrome? |journal=J. Med. Genet. |volume=35 |issue= 4 |pages= 273–8 |year= 1998 |pmid= 9598718 |doi=
*cite journal | author=Knights KM, Gasser R, Klemisch W |title=In vitro metabolism of acitretin by human liver microsomes: evidence of an acitretinoyl-coenzyme A thioester conjugate in the transesterification to etretinate. |journal=Biochem. Pharmacol. |volume=60 |issue= 4 |pages= 507–16 |year= 2000 |pmid= 10874125 |doi=
*cite journal | author=Cao Y, Dave KB, Doan TP, Prescott SM |title=Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma. |journal=Cancer Res. |volume=61 |issue= 23 |pages= 8429–34 |year= 2002 |pmid= 11731423 |doi=
*cite journal | author=Meloni I, Muscettola M, Raynaud M, "et al." |title=FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation. |journal=Nat. Genet. |volume=30 |issue= 4 |pages= 436–40 |year= 2002 |pmid= 11889465 |doi= 10.1038/ng857
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Longo I, Frints SG, Fryns JP, "et al." |title=A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients. |journal=J. Med. Genet. |volume=40 |issue= 1 |pages= 11–7 |year= 2003 |pmid= 12525535 |doi=
*cite journal | author=Sung YK, Hwang SY, Park MK, "et al." |title=Fatty acid-CoA ligase 4 is overexpressed in human hepatocellular carcinoma. |journal=Cancer Sci. |volume=94 |issue= 5 |pages= 421–4 |year= 2003 |pmid= 12824887 |doi=
*cite journal | author=Verot L, Alloisio N, Morlé L, "et al." |title=Localization of a non-syndromic X-linked mental retardation gene (MRX80) to Xq22-q24. |journal=Am. J. Med. Genet. A |volume=122 |issue= 1 |pages= 37–41 |year= 2004 |pmid= 12949969 |doi= 10.1002/ajmg.a.20221
*cite journal | author=Mashek DG, Bornfeldt KE, Coleman RA, "et al." |title=Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family. |journal=J. Lipid Res. |volume=45 |issue= 10 |pages= 1958–61 |year= 2005 |pmid= 15292367 |doi= 10.1194/jlr.E400002-JLR200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Liang YC, Wu CH, Chu JS, "et al." |title=Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase. |journal=World J. Gastroenterol. |volume=11 |issue= 17 |pages= 2557–63 |year= 2005 |pmid= 15849811 |doi=
*cite journal | author=Bhat SS, Schmidt KR, Ladd S, "et al." |title=Disruption of DMD and deletion of ACSL4 causing developmental delay, hypotonia, and multiple congenital anomalies. |journal=Cytogenet. Genome Res. |volume=112 |issue= 1-2 |pages= 170–5 |year= 2006 |pmid= 16276108 |doi= 10.1159/000087531
*cite journal | author=Sung YK, Park MK, Hong SH, "et al." |title=Regulation of cell growth by fatty acid-CoA ligase 4 in human hepatocellular carcinoma cells. |journal=Exp. Mol. Med. |volume=39 |issue= 4 |pages= 477–82 |year= 2007 |pmid= 17934335 |doi=

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