CTSZ

Cathepsin Z, also known as CTSZ, is a human gene.cite web | title = Entrez Gene: CTSZ cathepsin Z| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1522| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. At least two transcript variants of this gene have been found, but the full-length nature of only one of them has been determined.cite web | title = Entrez Gene: CTSZ cathepsin Z| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1522| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Santamaría I, Velasco G, Pendás AM, "et al." |title=Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16816–23 |year= 1998 |pmid= 9642240 |doi=
*cite journal | author=Nägler DK, Ménard R |title=Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions. |journal=FEBS Lett. |volume=434 |issue= 1-2 |pages= 135–9 |year= 1998 |pmid= 9738465 |doi=
*cite journal | author=Pungercar J, Ivanovski G |title=Identification and molecular cloning of cathepsin P, a novel human putative cysteine protease of the papain family. |journal=Pflugers Arch. |volume=439 |issue= 3 Suppl |pages= R116–8 |year= 2000 |pmid= 10653162 |doi=
*cite journal | author=Pungercar J, Viyjak A, Ivanovski G, Krizaj I |title=Tissue expression and immunolocalization of a novel human cathepsin P. |journal=Pflugers Arch. |volume=439 |issue= 3 Suppl |pages= R119–21 |year= 2000 |pmid= 10653163 |doi=
*cite journal | author=Sivaraman J, Nägler DK, Zhang R, "et al." |title=Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine. |journal=J. Mol. Biol. |volume=295 |issue= 4 |pages= 939–51 |year= 2000 |pmid= 10656802 |doi= 10.1006/jmbi.1999.3410
*cite journal | author=Guncar G, Klemencic I, Turk B, "et al." |title=Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease. |journal=Structure |volume=8 |issue= 3 |pages= 305–13 |year= 2000 |pmid= 10745011 |doi=
*cite journal | author=Deussing J, von Olshausen I, Peters C |title=Murine and human cathepsin Z: cDNA-cloning, characterization of the genes and chromosomal localization. |journal=Biochim. Biophys. Acta |volume=1491 |issue= 1-3 |pages= 93–106 |year= 2000 |pmid= 10760573 |doi=
*cite journal | author=Bonthron DT, Hayward BE, Moran V, Strain L |title=Characterization of TH1 and CTSZ, two non-imprinted genes downstream of GNAS1 in chromosome 20q13. |journal=Hum. Genet. |volume=107 |issue= 2 |pages= 165–75 |year= 2000 |pmid= 11030415 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Puzer L, Barros NM, Oliveira V, "et al." |title=Defining the substrate specificity of mouse cathepsin P. |journal=Arch. Biochem. Biophys. |volume=435 |issue= 1 |pages= 190–6 |year= 2005 |pmid= 15680921 |doi= 10.1016/j.abb.2004.12.007
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Lechner AM, Assfalg-Machleidt I, Zahler S, "et al." |title=RGD-dependent binding of procathepsin X to integrin alphavbeta3 mediates cell-adhesive properties. |journal=J. Biol. Chem. |volume=281 |issue= 51 |pages= 39588–97 |year= 2007 |pmid= 17065156 |doi= 10.1074/jbc.M513439200

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