KDELR1

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1, also known as KDELR1, is a human gene.cite web | title = Entrez Gene: KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10945| accessdate = ]

PBB_Summary
section_title =
summary_text = Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, which is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. The protein encoded by this gene was the first member of the family to be identified, and it encodes a protein structurally and functionally similar to the yeast ERD2 gene product.cite web | title = Entrez Gene: KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10945| accessdate = ]

References

ee also

KDELR2

Further reading

PBB_Further_reading
citations =
*cite journal | author=Pelham HR |title=The dynamic organisation of the secretory pathway. |journal=Cell Struct. Funct. |volume=21 |issue= 5 |pages= 413–9 |year= 1997 |pmid= 9118249 |doi=
*cite journal | author=Lewis MJ, Pelham HR |title=Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum. |journal=Cell |volume=68 |issue= 2 |pages= 353–64 |year= 1992 |pmid= 1310258 |doi=
*cite journal | author=Lewis MJ, Pelham HR |title=A human homologue of the yeast HDEL receptor. |journal=Nature |volume=348 |issue= 6297 |pages= 162–3 |year= 1990 |pmid= 2172835 |doi= 10.1038/348162a0
*cite journal | author=Townsley FM, Wilson DW, Pelham HR |title=Mutational analysis of the human KDEL receptor: distinct structural requirements for Golgi retention, ligand binding and retrograde transport. |journal=EMBO J. |volume=12 |issue= 7 |pages= 2821–9 |year= 1993 |pmid= 8392934 |doi=
*cite journal | author=Aoe T, Cukierman E, Lee A, "et al." |title=The KDEL receptor, ERD2, regulates intracellular traffic by recruiting a GTPase-activating protein for ARF1. |journal=EMBO J. |volume=16 |issue= 24 |pages= 7305–16 |year= 1998 |pmid= 9405360 |doi= 10.1093/emboj/16.24.7305
*cite journal | author=Smith JS, Tachibana I, Pohl U, "et al." |title=A transcript map of the chromosome 19q-arm glioma tumor suppressor region. |journal=Genomics |volume=64 |issue= 1 |pages= 44–50 |year= 2000 |pmid= 10708517 |doi= 10.1006/geno.1999.6101
*cite journal | author=Majoul I, Straub M, Hell SW, "et al." |title=KDEL-cargo regulates interactions between proteins involved in COPI vesicle traffic: measurements in living cells using FRET. |journal=Dev. Cell |volume=1 |issue= 1 |pages= 139–53 |year= 2001 |pmid= 11703931 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Matsuda A, Suzuki Y, Honda G, "et al." |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406
*cite journal | author=Yamamoto K, Hamada H, Shinkai H, "et al." |title=The KDEL receptor modulates the endoplasmic reticulum stress response through mitogen-activated protein kinase signaling cascades. |journal=J. Biol. Chem. |volume=278 |issue= 36 |pages= 34525–32 |year= 2003 |pmid= 12821650 |doi= 10.1074/jbc.M304188200
*cite journal | author=Bard F, Mazelin L, Péchoux-Longin C, "et al." |title=Src regulates Golgi structure and KDEL receptor-dependent retrograde transport to the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 46601–6 |year= 2004 |pmid= 12975382 |doi= 10.1074/jbc.M302221200
*cite journal | author=Breuza L, Halbeisen R, Jenö P, "et al." |title=Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47242–53 |year= 2004 |pmid= 15308636 |doi= 10.1074/jbc.M406644200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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